ID   ALDH3_YEAST             Reviewed;         506 AA.
AC   P54114;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-NOV-2008, entry version 62.
DE   RecName: Full=Aldehyde dehydrogenase [NAD(P)+] 2;
DE            EC=1.2.1.5;
GN   Name=ALD3; Synonyms=ALD4; OrderedLocusNames=YMR169C;
GN   ORFNames=YM8520.18C;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   MEDLINE=97313268; PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S.,
RA   Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A.,
RA   Rice P., Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   CHARACTERIZATION.
RX   MEDLINE=99337881; PubMed=10407263;
RX   DOI=10.1002/(SICI)1097-0061(199907)15:10A<829::AID-YEA423>3.0.CO;2-9;
RA   Navarro-Avino J.P., Prasad R., Miralles V.J., Benito R.M., Serrano R.;
RT   "A proposal for nomenclature of aldehyde dehydrogenases in
RT   Saccharomyces cerevisiae and characterization of the stress-inducible
RT   ALD2 and ALD3 genes.";
RL   Yeast 15:829-842(1999).
RN   [3]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   MEDLINE=22923965; PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA   Dephoure N., O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(P)(+) + H(2)O = an acid +
CC       NAD(P)H.
CC   -!- MISCELLANEOUS: Present with 172 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; Z49705; CAA89805.1; -; Genomic_DNA.
DR   PIR; S54527; S54527.
DR   RefSeq; NP_013892.1; -.
DR   HSSP; Q28399; 1O9J.
DR   PeptideAtlas; P54114; -.
DR   Ensembl; YMR169C; Saccharomyces cerevisiae.
DR   GeneID; 855205; -.
DR   GenomeReviews; Z71257_GR; YMR169C.
DR   KEGG; sce:YMR169C; -.
DR   NMPDR; fig|4932.3.peg.4942; -.
DR   CYGD; YMR169c; -.
DR   SGD; S000004779; ALD3.
DR   HOGENOM; P54114; -.
DR   BioCyc; MetaCyc:MON-13668; -.
DR   LinkHub; P54114; -.
DR   NextBio; 978699; -.
DR   ArrayExpress; P54114; -.
DR   GermOnline; YMR169C; Saccharomyces cerevisiae.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IDA:SGD.
DR   GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:EC.
DR   GO; GO:0019483; P:beta-alanine biosynthetic process; IMP:SGD.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006598; P:polyamine catabolic process; IGI:SGD.
DR   GO; GO:0006950; P:response to stress; IEP:SGD.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    506       Aldehyde dehydrogenase [NAD(P)+] 2.
FT                                /FTId=PRO_0000056440.
FT   ACT_SITE    268    268       Proton acceptor (By similarity).
FT   ACT_SITE    302    302       Nucleophile (By similarity).
FT   SITE        169    169       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   506 AA;  55385 MW;  11687E520B7E97DD CRC64;
     MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT SFQAANEKDV
     DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT LAALETLDAG KPFHSNAKQD
     LAQIIELTRY YAGAVDKFNM GETIPLTFNK FAYTLKVPFG VVAQIVPWNY PLAMACRKMQ
     GALAAGNTVI IKPAENTSLS LLYFATLIKK AGFPPGVVNV IPGYGSVVGK ALGTHMDIDK
     ISFTGSTKVG GSVLEASGQS NLKDITLECG GKSPALVFED ADLDKAIEWV ANGIFFNSGQ
     ICTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS STQYDRIKSY
     IERGKKEEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPETS KLLRDEIFGP VVVVSKFTNY
     DDALKLANDT CYGLASAVFT KDVKKAHMFA RDIKAGTVWI NQTNQEEAKV PFGGFKMSGI
     GRESGDTGVD NYLQIKSVHV DLSLDK
//