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UniProtKB/Swiss-Prot entry P53000

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PROA_CAMJE
Primary accession number P53000
Secondary accession number Q0PAV8
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on December 1, 2000 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name Gamma-glutamyl phosphate reductase
Synonyms GPR
EC 1.2.1.41
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
GSA dehydrogenase
Gene name
Name: proA
OrderedLocusNames: Cj0558c
From
Campylobacter jejuni [TaxID: 197] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Campylobacteraceae; Campylobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 43431 / TGH 9011 / Serotype O:3;
DOI=10.1007/BF00276880; PubMed=8341262 [NCBI, ExPASy, EBI, Israel, Japan]
Louie H., Chan V.L.;
"Cloning and characterization of the gamma-glutamyl phosphate reductase gene of Campylobacter jejuni.";
Mol. Gen. Genet. 240:29-35(1993).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCTC 11168 / Serotype O:2;
DOI=10.1038/35001088; PubMed=10688204 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S., Barrell B.G.;
"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences.";
Nature 403:665-668(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M74579; AAA23030.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL111168; CAL34704.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F81402; F81402.
S35213; S35213.
3D structure databases
HSSP Q9WYC9; 1O20. [HSSP ENTRY / PDB]
ModBase P53000.
Enzyme and pathway databases
BioCyc CJEJ192222:CJ0558C-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004350; Molecular function: glutamate-5-semialdehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006561; Biological process: proline biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00412; -; 1.
PBIL [Tree]
InterPro IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR000965; Gglut_pp_reduct.
IPR012134; Glu-5-SA_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PIRSF PIRSF000151; GPR; 1.
TIGRFAMs TIGR00407; proA; 1.
PROSITE PS01223; PROA; 1.
BLOCKS P53000.
Genome annotation databases
GenomeReviews AL111168_GR; Cj0558c.
KEGG cje:Cj0558c; -.
Phylogenomic databases
HOGENOM P53000; -.
Genome annotation databases
CMR P53000; Cj0558c.
Other
ProtoNet P53000.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   410  410     Gamma-glutamyl phosphate reductase. PRO_0000189710
CONFLICT   57    57        A -> K (in Ref. 1; AAA23030). 
CONFLICT   100   100        S -> N (in Ref. 1; AAA23030). 
CONFLICT   104   104        M -> I (in Ref. 1; AAA23030). 
CONFLICT   283   283        A -> T (in Ref. 1; AAA23030). 
CONFLICT   293   293        K -> E (in Ref. 1; AAA23030). 
Sequence information
Length: 410 AA [This is the length of the unprocessed precursor] Molecular weight: 46000 Da [This is the MW of the unprocessed precursor] CRC64: EB27A90652906668 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRNLLENIKK NSQKLLNLTP KDKEKIILKL AQILRENFKI ILEANKKDMA NFTKSGAMKD 

        70         80         90        100        110        120 
RLLLDEKRIL ALCEGLEKIA YIEDPIGKIS KGWKNYAGLS IQKMSIPLGL ICVIYEARPS 

       130        140        150        160        170        180 
LSAEIAALMI KSSNACVFKG GSEAKFTNEA IFTLVNKVLK EFDLQDCFAM FTQRDEILQI 

       190        200        210        220        230        240 
LAFDDLIDVI IPRGSSNMIQ EIANNTKIPL IKQNKGLCHA FVDQSANLDM ALKIILNAKC 

       250        260        270        280        290        300 
QRVSVCNALE TLLIHEKIAK NFISLLIPEF EKFKVKIHAH ENALAYFNNS NLKIFKANEN 

       310        320        330        340        350        360 
TFDTEWLDFA LSVKLVKDCD EAIEHINKHS SLHSETIISN DASNIAKFQR LINSSCIYAN 

       370        380        390        400        410 
ASTRFSDGGE FGFGGEVGIS TSKLHARGPM GIEDICTYKY IINGEGQIRE
P53000 in FASTA format

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