ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P52897

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name PGFS2_BOVIN
Primary accession number P52897
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 57)
Name and origin of the protein
Protein name Prostaglandin F synthase 2
Synonyms PGF synthase 2
PGFS2
PGF 2
EC 1.1.1.188
Prostaglandin F synthase II
PGFSII
Prostaglandin-D2 11 reductase 2
Gene name None
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1016/S0006-291X(05)80323-7; PubMed=1339268 [NCBI, ExPASy, EBI, Israel, Japan]
Kuchinke W., Barski O., Watanabe K., Hayaishi O.;
"A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli.";
Biochem. Biophys. Res. Commun. 183:1238-1246(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M86544; AAA30730.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E75572; JH0575.
RefSeq XP_001250623.1; -.
UniGene Bt.64820
3D structure databases
HSSP P52895; 1J96. [HSSP ENTRY / PDB]
SMR P52897; 2-323.
ModBase P52897.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0047017; Molecular function: prostaglandin-F synthase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0001516; Biological process: prostaglandin biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001395; Aldo/ket_red.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.100; Aldo/ket_red; 1.
PANTHER PTHR11732; Aldo/ket_red; 1.
Pfam PF00248; Aldo_ket_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00069; ALDKETRDTASE.
ProDom PD000288; Aldo/ket_red; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00798; ALDOKETO_REDUCTASE_1; 1.
PS00062; ALDOKETO_REDUCTASE_2; 1.
PS00063; ALDOKETO_REDUCTASE_3; 1.
Genome annotation databases
Ensembl ENSBTAG00000022570; Bos taurus. [Contig view]
GeneID 782922; -.
KEGG bta:782922; -.
Phylogenomic databases
HOVERGEN P52897; -.
Other
ProtoNet P52897.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Fatty acid biosynthesis; Lipid synthesis; NADP; Oxidoreductase; Prostaglandin biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   323  323     Prostaglandin F synthase 2. PRO_0000124647
NP_BIND   13    22  10     NADP (Potential). 
NP_BIND   217   280  64     NADP (By similarity). 
ACT_SITE   55    55        Proton donor (By similarity). 
BINDING   117   117        Substrate (By similarity). 
SITE   84    84  1     Lowers pKa of active site Tyr (By similarity). 
Sequence information
Length: 323 AA [This is the length of the unprocessed precursor] Molecular weight: 36742 Da [This is the MW of the unprocessed precursor] CRC64: 21A5BE0668D07A2C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDPKSQRVKF NDGHFIPVLG FGTYAPEEVP KSEALEATKF AIEVGFRHVD SAHLYQNEEQ 

        70         80         90        100        110        120 
VGQAIRSKIA DGTVKREDIF YTSKLWCNSL QPELVRPALE KSLQNLQLDY VDLYIIHSPV 

       130        140        150        160        170        180 
SLKPGNKFVP KDESGKLIFD SVDLCHTWEA LEKCKDAGLT KSIGVSNFNH KQLEKILNKP 

       190        200        210        220        230        240 
GLKYKPVCNQ VECHPYLNQS KLLEFCKSHD IVLVAYAALG AQLLSEWVNS NNPVLLEDPV 

       250        260        270        280        290        300 
LCAIAKKHKQ TPALVALRYQ VQRGVVVLAK SFNKKRIKEN MQVFDFELTP EDMKAIDGLN 

       310        320 
RNTRYYDFQQ GIGHPEYPFS EEY
P52897 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by au flag APAF Australia Mirror sites: Brazil Canada China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!