ID   CYSH_THIRO              Reviewed;         239 AA.
AC   P52672;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-NOV-2008, entry version 51.
DE   RecName: Full=Phosphoadenosine phosphosulfate reductase;
DE            EC=1.8.4.8;
DE   AltName: Full=PAPS reductase, thioredoxin dependent;
DE   AltName: Full=PAdoPS reductase;
DE   AltName: Full=3'-phosphoadenylylsulfate reductase;
DE   AltName: Full=PAPS sulfotransferase;
GN   Name=cysH;
OS   Thiocapsa roseopersicina.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Chromatiaceae; Thiocapsa.
OX   NCBI_TaxID=1058;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 219 / 6311;
RX   MEDLINE=96305328; PubMed=8695637;
RA   Bruehl A., Haverkamp T., Gisselmann G., Schwenn J.D.;
RT   "A cDNA clone from Arabidopsis thaliana encoding plastidic
RT   ferredoxin:sulfite reductase.";
RL   Biochim. Biophys. Acta 1295:119-124(1996).
CC   -!- FUNCTION: Reduction of activated sulfate into sulfite.
CC   -!- CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + sulfite +
CC       thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
CC   -!- PATHWAY: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite
CC       from sulfate: step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PAPS reductase family. CysH subfamily.
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DR   EMBL; Z23169; CAA80690.1; -; Genomic_DNA.
DR   PIR; S34193; S34193.
DR   HSSP; P17854; 1SUR.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0004604; F:phosphoadenylyl-sulfate reductase (thioredo...; IEA:HAMAP.
DR   GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR   GO; GO:0019344; P:cysteine biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0019379; P:sulfate assimilation, phosphoadenylyl sulfa...; IEA:HAMAP.
DR   HAMAP; MF_00063; -; 1.
DR   InterPro; IPR004511; CysH.
DR   InterPro; IPR002500; PAPS_reduct.
DR   InterPro; IPR011800; PAPS_reductase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
DR   Pfam; PF01507; PAPS_reduct; 1.
DR   TIGRFAMs; TIGR00434; cysH; 1.
DR   TIGRFAMs; TIGR02057; PAPS_reductase; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Oxidoreductase.
FT   CHAIN         1    239       Phosphoadenosine phosphosulfate
FT                                reductase.
FT                                /FTId=PRO_0000100651.
SQ   SEQUENCE   239 AA;  27695 MW;  8677B99E6649255D CRC64;
     MSKPDLDAFL HGDDAALRET NRRLESMPAE DRVRWALEHL PPQHVLSSSF GTQSAVMLHL
     VSRQMPEIPV ILVDTGYLFP ETYRLVDALT DRFGLNLKVY RPALSPAWQE AGLGRLWEQG
     ADGIERYNRL NKIDPMERAL RDLDAGTWFA GLRRQQANSR AELPVLRRQD GRIKFHPIID
     WHRPRRARYL RRHDLPDHPL RDQGYVSIGD VHTTVPLLPG MLEEETRFFG IKRECGLHR
//