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UniProtKB/Swiss-Prot entry P52484

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UBC21_CAEEL
Primary accession number P52484
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on September 5, 2006 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 55)
Name and origin of the protein
Protein name Probable ubiquitin-conjugating enzyme E2 21
Synonyms EC 6.3.2.19
Ubiquitin-protein ligase 21
Ubiquitin carrier protein 21
Gene name
Name: ubc-21
ORFNames: C06E2.3
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U39674; AAA80415.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T15432; T15432.
RefSeq NP_509502.2; -.
UniGene Cel.25724
3D structure databases
HSSP P21734; 1FZY. [HSSP ENTRY / PDB]
ModBase P52484.
Organism-specific databases
WormBase WBGene00006716; ubc-21.
WormPep C06E2.3; CE40013. [WormPep / WorfDB]
Gene expression databases
ArrayExpress P52484; -.
Ontologies
GO
GO:0004842; Molecular function: ubiquitin-protein ligase activity (inferred from electronic annotation from EC).
GO:0043687; Biological process: post-translational protein modification (inferred from electronic annotation from InterPro).
GO:0051246; Biological process: regulation of protein metabolic process (inferred from electronic annotation from InterPro).
GO:0006511; Biological process: ubiquitin-dependent protein catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR015940; UBA/transl_elong_EF1B_N_euk.
IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.
Gene3D G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.
PANTHER PTHR11621; UBQ-conjugat_E2; 1.
Pfam PF00179; UQ_con; 1.
Pfam graphical view of domain structure.
ProDom PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00212; UBCc; 1.
SMART graphical view of domain structure.
PROSITE PS50030; UBA; 1.
PS00183; UBIQUITIN_CONJUGAT_1; 1.
PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl C06E2.3; Caenorhabditis elegans. [Contig view]
GeneID 182321; -.
KEGG cel:C06E2.3; -.
Other
NextBio 917164; -.
ProtoNet P52484.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Ligase; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   229  229     Probable ubiquitin-conjugating enzyme E2 21. PRO_0000082518
DOMAIN   187   229  43     UBA. 
ACT_SITE   121   121        Glycyl thioester intermediate (By similarity). 
Sequence information
Length: 229 AA [This is the length of the unprocessed precursor] Molecular weight: 26065 Da [This is the MW of the unprocessed precursor] CRC64: 7FBE05784F66386C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSVSKLNKMQ FSDKMSNLAL ARVTRKCKEV ANASDITEAG IHVEIKENNL MDIKGFIKGP 

        70         80         90        100        110        120 
EGTPYAGGTF EIKVDIPEHY PFEPPKVTEI IFHIRAFEYI QAKFVTRIWH PNISSQTGTI 

       130        140        150        160        170        180 
CLDILKDKWT ASLTLRTVLL SLQAMLCSPE PSDPQDAVVA KQFINNYPMF TATAVYWTSY 

       190        200        210        220 
FANSKKDVEP DFNRKVGRLI EMGIRETEAI VYLSCNNWKL EQALQFIFD
P52484 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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