ID   P5CR_VIBAL              Reviewed;         278 AA.
AC   P52053;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-NOV-2008, entry version 40.
DE   RecName: Full=Pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   Name=proC;
OS   Vibrio alginolyticus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=138-2;
RX   MEDLINE=97137009; PubMed=8982386; DOI=10.1016/S0005-2728(96)00097-7;
RA   Nakamura T., Katoh Y., Shimizu Y., Matsuba Y., Unemoto T.;
RT   "Cloning and sequencing of novel genes from Vibrio alginolyticus that
RT   support the growth of K+ uptake-deficient mutant of Escherichia
RT   coli.";
RL   Biochim. Biophys. Acta 1277:201-208(1996).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; D50472; BAA09063.1; -; Genomic_DNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cytoplasm; NADP; Oxidoreductase;
KW   Proline biosynthesis.
FT   CHAIN         1    278       Pyrroline-5-carboxylate reductase.
FT                                /FTId=PRO_0000187311.
SQ   SEQUENCE   278 AA;  29815 MW;  50359E5EF97CD68B CRC64;
     MMEIRQMEHK KIAFIGAGNM VRAIVSGLVA NGYPAQNITA TAPSEARRLP LEQDFGIRTT
     SDNIQAATEA DVVVLSVKPQ MMADVCKPLQ AIDFTNKLVI SIAAGINCSR LDDMLATKLN
     LVRVMPNTPS QLGLGMSGLF APIHVTEHDK AFAAELMEAV GKVCWVEQES GINNVIAAAG
     SAPAYFFLFM EAMQAEAIAQ GFDKESARLL VQQAALGAAS MVVSNPETEL STLRENVTSK
     GGTTAEALRT FNEHQLSDIV AKAMQAAVAR AEEMEKLF
//