ID   GPXC_DIRIM              Reviewed;         221 AA.
AC   P52033;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-NOV-2008, entry version 45.
DE   RecName: Full=Glutathione peroxidase;
DE            EC=1.11.1.9;
DE   AltName: Full=Di29;
DE   Flags: Precursor;
OS   Dirofilaria immitis (Canine heartworm).
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Spirurida; Filarioidea;
OC   Onchocercidae; Dirofilaria.
OX   NCBI_TaxID=6287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Venkatakrishnaiah L., James E.;
RL   Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   MEDLINE=98162489; PubMed=9501847; DOI=10.1006/expr.1998.4217;
RA   Tripp C.A., Frank R.S., Selkirk M.E., Tang L., Mika-Grieve M.,
RA   Frank G.R., Grieve R.B.;
RT   "Dirofilaria immitis: molecular cloning and expression of a cDNA
RT   encoding a selenium-independent secreted glutathione peroxidase.";
RL   Exp. Parasitol. 88:43-50(1998).
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione
CC       disulfide + 2 H(2)O.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR   EMBL; U04693; AAA16224.1; -; mRNA.
DR   EMBL; U87457; AAB58573.1; -; mRNA.
DR   EMBL; U87458; AAB58574.1; -; Genomic_DNA.
DR   HSSP; P00435; 1GP1.
DR   PeroxiBase; 3752; DiGPx01.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR000889; Glut_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Oxidoreductase; Peroxidase; Secreted; Signal.
FT   SIGNAL        1     19       Potential.
FT   CHAIN        20    221       Glutathione peroxidase.
FT                                /FTId=PRO_0000013094.
FT   ACT_SITE     72     72       By similarity.
FT   CARBOHYD     28     28       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     87     87       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     90     90       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   221 AA;  25453 MW;  88FFF848D567CF28 CRC64;
     MFIQLLILSY AILLQLIATQ VADKQLPNLT KQCEPTSQTI YDFHVPTLDG SEKSLAEYRG
     KVLLLVNVAT YCAYTFQYND FNPMLENNSN GTLKILAFPC NQFLLQEPAE NHELLNGLKY
     VRPGNGWEPH GNMHIFGKVE VNGDDHHPLY KFLKEHCPQT VPIIGDRHQL MYNPIGTNDI
     IWNFEKFLID KKGHPRYRFH PSAWVQGSVI APFIDELERE I
//