Gonadoliberin-2
     (Gonadoliberin II)
     (Luteinizing hormone-releasing hormone II)
     (LH-RH II)
     (Gonadotropin-releasing hormone II)
     (GnRH II)
     (Luliberin II)
GnRH-associated peptide 2
     (GnRH-associated peptide II)

Gene name

Name:

gnrh2

From

Sparus aurata (Gilthead sea bream)

[TaxID: 8175]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Percoidei; Sparidae; Sparus.

Protein existence

1: Evidence at protein level;

References

[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Brain; DOI=10.1006/gcen.1998.7138; PubMed=9843645 [NCBI, ExPASy, EBI, Israel, Japan] Holland M.C.H., Gothilf Y., Meiri I., King J.A., Okuzawa K., Elizur A., Zohar Y.; "Levels of the native forms of GnRH in the pituitary of the gilthead seabream, Sparus aurata, at several characteristic stages of the gonadal cycle."; Gen. Comp. Endocrinol. 112:394-405(1998).
[2]	PROTEIN SEQUENCE OF 24-33, AND MASS SPECTROMETRY. TISSUE=Brain; PubMed=7991588 [NCBI, ExPASy, EBI, Israel, Japan] Powell J.F.F., Zohar Y., Elizur A., Park M., Fischer W.H., Craig A.G., Rivier J.E., Lovejoy D.A., Sherwood N.M.; "Three forms of gonadotropin-releasing hormone characterized from brains of one species."; Proc. Natl. Acad. Sci. U.S.A. 91:12081-12085(1994).

Comments

FUNCTION: Stimulates the secretion of gonadotropins.
SUBCELLULAR LOCATION: Secreted.
MASS SPECTROMETRY: Mass=1236.6; Method=MALDI; Range=24-33; Source=PubMed:7991588;.
SIMILARITY: Belongs to the GnRH family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U30325; AAA75447.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P51925.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from InterPro).
GO:0005179;	Molecular function: hormone activity (inferred from electronic annotation from InterPro).
GO:0007275;	Biological process: multicellular organismal development (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR002012; GnRH.
Graphical view of domain structure.

PANTHER

PTHR10522; GnRH; 1.

Pfam

PF00446; GnRH; 1.
Pfam graphical view of domain structure.

PROSITE

PS00473; GNRH; 1.

Phylogenomic databases

HOVERGEN

P51925; -.

Other

ProtoNet

P51925.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 23`	`23`
`CHAIN`	`24 85`	`62`	`Progonadoliberin-2.`	`PRO_0000012496`
`PEPTIDE`	`24 33`	`10`	`Gonadoliberin-2.`	`PRO_0000012497`
`PEPTIDE`	`37 85`	`49`	`GnRH-associated peptide 2.`	`PRO_0000012498`
`MOD_RES`	`24 24`		`Pyrrolidone carboxylic acid.`
`MOD_RES`	`33 33`		`Glycine amide.`

Sequence information

Length: 85 AA [This is the length of the unprocessed precursor]

Molecular weight: 9543 Da [This is the MW of the unprocessed precursor]

CRC64: B53165C1227722CC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MCVSRLVLLL GLLLCVGAQL SNGQHWSHGW YPGGKRELDS FGTSEISEEI KLCEAGECSY 

        70         80 
LTPQRRSVLR NILLDALARE LQKRK

P51925 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools