Gonadoliberin-1
     (Gonadoliberin I)
     (Luteinizing hormone-releasing hormone I)
     (LH-RH I)
     (Gonadotropin-releasing hormone I)
     (GnRH-I)
     (Luliberin I)
GnRH-associated peptide 1
     (GnRH-associated peptide I)

Gene name

Name:

gnrh1

From

Sparus aurata (Gilthead sea bream)

[TaxID: 8175]

Taxonomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Percoidei; Sparidae; Sparus.

Protein existence

1: Evidence at protein level;

References

[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Brain; PubMed=7749463 [NCBI, ExPASy, EBI, Israel, Japan] Gothilf Y., Elizur A., Chow M., Chen T.T., Zohar Y.; "Molecular cloning and characterization of a novel gonadotropin-releasing hormone from the gilthead seabream (Sparus aurata)."; Mol. Mar. Biol. Biotechnol. 4:27-35(1995).
[2]	PROTEIN SEQUENCE OF 26-35, AND MASS SPECTROMETRY. TISSUE=Brain; PubMed=7991588 [NCBI, ExPASy, EBI, Israel, Japan] Powell J.F.F., Zohar Y., Elizur A., Park M., Fischer W.H., Craig A.G., Rivier J.E., Lovejoy D.A., Sherwood N.M.; "Three forms of gonadotropin-releasing hormone characterized from brains of one species."; Proc. Natl. Acad. Sci. U.S.A. 91:12081-12085(1994).

Comments

FUNCTION: Stimulates the secretion of gonadotropins.
SUBCELLULAR LOCATION: Secreted.
MASS SPECTROMETRY: Mass=1113.6; Method=MALDI; Range=26-35; Source=PubMed:7991588;.
SIMILARITY: Belongs to the GnRH family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U30320; AAA75469.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P51919.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from InterPro).
GO:0005179;	Molecular function: hormone activity (inferred from electronic annotation from InterPro).
GO:0007275;	Biological process: multicellular organismal development (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR002012; GnRH.
IPR004079; GonadoliberinI.
Graphical view of domain structure.

PANTHER

PTHR10522; GnRH; 1.

Pfam

PF00446; GnRH; 1.
Pfam graphical view of domain structure.

PRINTS

PR01541; GONADOLIBRNI.

PROSITE

PS00473; GNRH; 1.

Phylogenomic databases

HOVERGEN

P51919; -.

Other

ProtoNet

P51919.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 25`	`25`
`CHAIN`	`26 95`	`70`	`Progonadoliberin-1.`	`PRO_0000012444`
`PEPTIDE`	`26 35`	`10`	`Gonadoliberin-1.`	`PRO_0000012445`
`PEPTIDE`	`39 95`	`57`	`GnRH-associated peptide 1 (Potential).`	`PRO_0000012446`
`MOD_RES`	`26 26`		`Pyrrolidone carboxylic acid.`
`MOD_RES`	`35 35`		`Glycine amide.`

Sequence information

Length: 95 AA [This is the length of the unprocessed precursor]

Molecular weight: 10753 Da [This is the MW of the unprocessed precursor]

CRC64: 49313FD6FD6B87DA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAPQTSNLWI LLLLVVVMMM SQGCCQHWSY GLSPGGKRDL DSLSDTLGNI IERFPHVDSP 

        70         80         90 
CSVLGCVEEP HVPRMYRMKG FIGSERDIGH RMYKK

P51919 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools