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UniProtKB/Swiss-Prot entry P51918


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GON1_HAPBU
Primary accession number P51918
Secondary accession number O93387
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on May 30, 2000 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 51)
Name and origin of the protein
Protein name Progonadoliberin-1 [Precursor]
Synonym Progonadoliberin I
Contains Gonadoliberin-1
     (Gonadoliberin I)
     (Luteinizing hormone-releasing hormone I)
     (LH-RH I)
     (Gonadotropin-releasing hormone I)
     (GnRH-I)
     (Luliberin I)
GnRH-associated peptide 1
     (GnRH-associated peptide I)
Gene name
Name: gnrh1
From
Haplochromis burtoni (Burton's mouthbrooder) [TaxID: 8153] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Labroidei; Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini; Haplochromis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7667296 [NCBI, ExPASy, EBI, Israel, Japan]
White S.A., Kasten T.L., Bond C.T., Adelman J.P., Fernald R.D.;
"Three gonadotropin-releasing hormone genes in one organism suggest novel roles for an ancient peptide.";
Proc. Natl. Acad. Sci. U.S.A. 92:8363-8367(1995).
[2]
NUCLEOTIDE SEQUENCE.
DOI=10.1006/gcen.1998.7142; PubMed=9843638 [NCBI, ExPASy, EBI, Israel, Japan]
White R.B., Fernald R.D.;
"Ontogeny of gonadotropin-releasing hormone (GnRH) gene expression reveals a distinct origin for GnRH-containing neurons in the midbrain.";
Gen. Comp. Endocrinol. 112:322-329(1998).
[3]
PROTEIN SEQUENCE OF 23-32, AND MASS SPECTROMETRY.
TISSUE=Pituitary;
DOI=10.1016/0167-0115(95)00014-3; PubMed=7644702 [NCBI, ExPASy, EBI, Israel, Japan]
Powell J.F.F., Fischer W.H., Park M., Craig A.G., Rivier J.E., White S.A., Francis R.C., Fernald R.D., Licht P., Warby C., Sherwood N.M.;
"Primary structure of solitary form of gonadotropin-releasing hormone (GnRH) in cichlid pituitary; three forms of GnRH in brain of cichlid and pumpkinseed fish.";
Regul. Pept. 57:43-53(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U31865; AAC59691.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF076961; AAC27716.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I50739; I50739.
3D structure databases
ModBase P51918.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (non-traceable author statement from UniProtKB).
GO:0005183; Molecular function: gonadotropin hormone-releasing hormone activity (non-traceable author statement from UniProtKB).
GO:0007275; Biological process: multicellular organismal development (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR002012; GnRH.
IPR004079; GonadoliberinI.
Graphical view of domain structure.
PANTHER PTHR10522; GnRH; 1.
Pfam PF00446; GnRH; 1.
Pfam graphical view of domain structure.
PRINTS PR01541; GONADOLIBRNI.
PROSITE PS00473; GNRH; 1.
Phylogenomic databases
HOVERGEN P51918; -.
Other
ProtoNet P51918.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
SIGNAL   1   22  22      
CHAIN   23   94  72     Progonadoliberin-1. PRO_0000012432
PEPTIDE   23   32  10     Gonadoliberin-1. PRO_0000012433
PEPTIDE   36   94  59     GnRH-associated peptide 1 (Potential). PRO_0000012434
MOD_RES   23   23        Pyrrolidone carboxylic acid. 
MOD_RES   32   32        Glycine amide. 
CONFLICT   86   94        ENGHRTFKK -> KMDTGHSRNERFL (in Ref. 1; AAC59691). 
Sequence information
Length: 94 AA [This is the length of the unprocessed precursor] Molecular weight: 10382 Da [This is the MW of the unprocessed precursor] CRC64: E57DBA83333278D7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAKILALWL LLAGTVFPQG CCQHWSYGLS PGGKRDLDNF SDTLGNMVEE FPRVEAPCSV 

        70         80         90 
FGCAEESPFA KMYRVKGLLA SVAERENGHR TFKK 

P51918 in FASTA format

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