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UniProtKB/Swiss-Prot entry P51658

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHB2_MOUSE
Primary accession number P51658
Secondary accession number O08898
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on November 1, 1997 (Sequence version 2)
Annotations were last modified on    September 23, 2008 (Entry version 66)
Name and origin of the protein
Protein name Estradiol 17-beta-dehydrogenase 2
Synonyms EC 1.1.1.62
Testosterone 17-beta-dehydrogenase
EC 1.1.1.63
17-beta-hydroxysteroid dehydrogenase 2
17-beta-HSD 2
Gene name
Name: Hsd17b2
Synonyms: Edh17b2
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/c;
TISSUE=Liver;
PubMed=9224647 [NCBI, ExPASy, EBI, Israel, Japan]
Mustonen M.;
"Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.";
Biochem. J. 325:199-205(1997).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] OF 1-358.
STRAIN=BALB/c;
Stoffel W., Weiss B.;
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y09517; CAA70706.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X95685; CAA64982.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_032316.2; -.
UniGene Mm.276466
3D structure databases
HSSP P14061; 1FDS. [HSSP ENTRY / PDB]
ModBase P51658.
Organism-specific databases
MGI MGI:1096386; Hsd17b2.
Gene expression databases
ArrayExpress P51658; -.
CleanEx MM_HSD17B2; -.
GermOnline ENSMUSG00000031844; Mus musculus.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
BLOCKS P51658.
Genome annotation databases
Ensembl ENSMUSG00000031844; Mus musculus. [Contig view]
GeneID 15486; -.
KEGG mmu:15486; -.
Phylogenomic databases
HOGENOM P51658; -.
HOVERGEN P51658; -.
Other
SOURCE Hsd17b2; Mus musculus.
ProtoNet P51658.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Lipid synthesis; Membrane; NAD; Oxidoreductase; Signal-anchor; Steroid biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   381  381     Estradiol 17-beta-dehydrogenase 2. PRO_0000054571
TRANSMEM   4    24  21     Signal-anchor for type II membrane protein (Potential). 
NP_BIND   83   112  30     NAD (By similarity). 
ACT_SITE   233   233        Proton acceptor (By similarity). 
BINDING   220   220        Substrate (By similarity). 
CONFLICT   36    37        QA -> RP (in Ref. 2; CAA64982). 
Sequence information
Length: 381 AA [This is the length of the unprocessed precursor] Molecular weight: 41836 Da [This is the MW of the unprocessed precursor] CRC64: 74A62797947E6086 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSPFASESAW LCLAAAAVLG GTLLCGCRSG RQLRSQAVCL AGLWGGACLL SLSLLCTLFL 

        70         80         90        100        110        120 
LSVACFLLLY MSSSDQDLLP VDQKAVLVTG ADSGFGHGLA KHLDKLGFTV FAGVLDKEGP 

       130        140        150        160        170        180 
GAEELRKHCS ERLSVLQMDV TKPEQIKDAH SKVTEKIQDK GLWAVVNNAG VFHLPIDGEL 

       190        200        210        220        230        240 
IPMSIYRKCM AVNFFGTVEV TKAFLPLLRK SKGRLVNVSS MGGTVPLQMT SAYAATKAAL 

       250        260        270        280        290        300 
TMFSTIIRQE LDKWGVKVVT IKPGGFKTNI TGSQDIWDKM EKEILDHFSK DIQENYGQDY 

       310        320        330        340        350        360 
VHTQKLIIPT LKERSNPDIT PVLRDIQHAI SARNPSSFYY PGRMAYLWVC LAAYCPTSLL 

       370        380 
DYVIKKGFYP QPTPRALRTV H
P51658 in FASTA format

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