ID   DHB1_MOUSE              Reviewed;         344 AA.
AC   P51656;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-NOV-2008, entry version 62.
DE   RecName: Full=Estradiol 17-beta-dehydrogenase 1;
DE            EC=1.1.1.62;
DE   AltName: Full=17-beta-hydroxysteroid dehydrogenase type 1;
DE            Short=17-beta-HSD 1;
GN   Name=Hsd17b1; Synonyms=Edh17b1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   MEDLINE=96195656; PubMed=8612620;
RA   Nokelainen P., Puranen T., Peltoketo H., Orava M., Vihko P., Vihko R.;
RT   "Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type
RT   1 and characterization of enzyme activity.";
RL   Eur. J. Biochem. 236:482-490(1996).
CC   -!- FUNCTION: Favors the reduction of estrogens and androgens. Uses
CC       preferentially NADH.
CC   -!- CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)(+) = estrone +
CC       NAD(P)H.
CC   -!- PATHWAY: Steroid biosynthesis; estrogen biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; X89627; CAA61770.1; -; mRNA.
DR   PIR; S62652; S62652.
DR   RefSeq; NP_034605.1; -.
DR   UniGene; Mm.188939; -.
DR   HSSP; P14061; 1FDW.
DR   SMR; P51656; 4-284.
DR   Ensembl; ENSMUSG00000019301; Mus musculus.
DR   GeneID; 15485; -.
DR   KEGG; mmu:15485; -.
DR   MGI; MGI:105077; Hsd17b1.
DR   HOGENOM; P51656; -.
DR   HOVERGEN; P51656; -.
DR   NextBio; 288346; -.
DR   ArrayExpress; P51656; -.
DR   CleanEx; MM_HSD17B1; -.
DR   GermOnline; ENSMUSG00000019301; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006703; P:estrogen biosynthetic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR011348; 17beta_DHase.
DR   InterPro; IPR002198; DHase_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410:SF47; 17beta_DH; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PIRSF; PIRSF000095; 17beta-HSD; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lipid synthesis; NAD; Oxidoreductase; Steroid biosynthesis.
FT   CHAIN         1    344       Estradiol 17-beta-dehydrogenase 1.
FT                                /FTId=PRO_0000054568.
FT   NP_BIND       3     32       NAD (By similarity).
FT   ACT_SITE    156    156       Proton acceptor (By similarity).
FT   BINDING     143    143       Substrate (By similarity).
SQ   SEQUENCE   344 AA;  36785 MW;  0335C473F453C14A CRC64;
     MDPTVVLITG CSSGIGMHLA VRLASDRSQS FKVYATLRDL KAQGPLLEAA RTQGCPPGSL
     EILELDVRDS KSVAAAQACV TEGRVDVLVC NAGRGLFGPL EAHELNAVGA VLDVNVLGTI
     RMLQAFLPDM KRRHSGRVLV TASVGGLMGL PFHEVYCASK FALEGLCESL AILLPLFGVH
     VSLIECGAVH TAFYEKLVGG PGGALERADA QTRHLFAHYL RGYEQALSEA QDPEEVTELF
     LTAMRAPQPA LRYFSTNRFL PLARMRTEDP SGSSYVAAMH QEAFSNLQTQ ENAKAGAQVP
     GVSDTASSAL ICLPECAIPR VASELGWSAS DKPGQDNSCY QQKI
//