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UniProtKB/Swiss-Prot entry P51615

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAOX_VITVI
Primary accession number P51615
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 46)
Name and origin of the protein
Protein name NADP-dependent malic enzyme
Synonyms NADP-ME
EC 1.1.1.40
Gene name None
From
Vitis vinifera (Grape) [TaxID: 29760] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; Vitales; Vitaceae; Vitis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Thompson;
TISSUE=Fruit;
DOI=10.1104/pp.107.3.1009; PubMed=7716227 [NCBI, ExPASy, EBI, Israel, Japan]
Franke K.E., Adams D.O.;
"Cloning of a full-length cDNA for malic enzyme (EC 1.1.1.40) from grape berries.";
Plant Physiol. 107:1009-1010(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L34836; AAA67087.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P40927; 1GQ2. [HSSP ENTRY / PDB]
ModBase P51615.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004473; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity (inferred from electronic annotation from EC).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS P51615.
ProtoNet P51615.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Metal-binding; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   591  591     NADP-dependent malic enzyme. PRO_0000160204
NP_BIND   335   351  17     NADP (By similarity). 
ACT_SITE   139   139        Proton donor (By similarity). 
ACT_SITE   210   210        Proton acceptor (By similarity). 
METAL   282   282        Divalent metal cation (By similarity). 
METAL   283   283        Divalent metal cation (By similarity). 
METAL   306   306        Divalent metal cation (By similarity). 
BINDING   192   192        NAD (By similarity). 
BINDING   306   306        NAD (By similarity). 
BINDING   447   447        NAD (By similarity). 
SITE   306   306  1     Important for activity (By similarity). 
Sequence information
Length: 591 AA [This is the length of the unprocessed precursor] Molecular weight: 65227 Da [This is the MW of the unprocessed precursor] CRC64: FD78B0976A7C4744 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MESTLKDIRD GASVLDLDPK ATVGGGVEDL YGEDFATEDQ LVTPWTVSVA SGYSLLRDPR 

        70         80         90        100        110        120 
HNKGLAFNDK ERDAHYLCGL LPPVVSTQEL QERKLMNSIR QYQVPLQKYM AMMDLQERNE 

       130        140        150        160        170        180 
RLFYKLLIDN VEELLPVVYT PTVGEACQKY GSIFRRPQGL YISLKEKGKI LEVLKNWPER 

       190        200        210        220        230        240 
RIQVIVVTDG ERILGLGDLG CQGMGIPVGK LSLYTALGGV RPSACLPITI DVGTNNEKLL 

       250        260        270        280        290        300 
ANEFYIGLKQ RRATGKEYSE FLQEFMSPVK QNYGEKVLIQ FEDFANHNAF DLLAKYGTTH 

       310        320        330        340        350        360 
LAFNDDIQGT ASVVLAGIVS ALRLLGGTLA DHKFLFLGAG EAGTGIAELI ALEMSKQTKC 

       370        380        390        400        410        420 
PIEETRKKIW LVDSKGLIVG SRKDSLQQFK KPWAHEHEPV KDLLDAVKVI KPTVLIGSSG 

       430        440        450        460        470        480 
VGKAFTKEVI EAMASCNEKP LILALSNPTS QSECTAEEAY TWTQGRAIFA SGSPFDPVEY 

       490        500        510        520        530        540 
NGKTFVPGQA NNAYIFPGLG MGLVISGAIR VHDEMLLAAS EALARQVTQE NFDKGLIYPP 

       550        560        570        580        590 
FSNIRKISAH IAANVAAKAY ELGLATRLPQ PENLVKYAES CMYSPVYRSY R
P51615 in FASTA format

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