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UniProtKB/Swiss-Prot entry P51553

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH3G_HUMAN
Primary accession number P51553
Secondary accession number Q9BUU5
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 88)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial [Precursor]
Synonyms EC 1.1.1.41
Isocitric dehydrogenase
NAD(+)-specific ICDH
Gene name
Name: IDH3G
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Brain;
DOI=10.1006/geno.1997.4822; PubMed=9286695 [NCBI, ExPASy, EBI, Israel, Japan]
Brenner V., Nyakatura G., Rosenthal A., Platzer M.;
"Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.";
Genomics 44:8-14(1997).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
DOI=10.1074/jbc.274.52.36866; PubMed=10601238 [NCBI, ExPASy, EBI, Israel, Japan]
Kim Y.-O., Koh H.-J., Kim S.-H., Jo S.-H., Huh J.-W., Jeong K.-S., Lee I.J., Song B.J., Huh T.-L.;
"Identification and functional characterization of a novel, tissue-specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform.";
J. Biol. Chem. 274:36866-36875(1999).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
 SUBCELLULAR LOCATION.
DOI=10.1093/embo-reports/kvd058; PubMed=11256614 [NCBI, ExPASy, EBI, Israel, Japan]
Simpson J.C., Wellenreuther R., Poustka A., Pepperkok R., Wiemann S.;
"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.";
EMBO Rep. 1:287-292(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z68907; CAA93143.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z68129; CAA92214.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U52111; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
U40272; AAD09357.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000933; AAH00933.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001902; AAH01902.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_004126.1; -.
UniGene Hs.410197
3D structure databases
HSSP P00351; 1XAA. [HSSP ENTRY / PDB]
ModBase P51553.
Protein-protein interaction databases
IntAct P51553; -.
PTM databases
PhosphoSite P51553; -.
Enzyme and pathway databases
Reactome REACT_1046; Pyruvate metabolism and TCA cycle.
Organism-specific databases
H-InvDB HIX0017139; -.
HGNC HGNC:5386; IDH3G.
GenAtlas IDH3G.
HPA HPA000425; -.
HPA002017; -.
MIM 300089; gene. [NCBI / EBI]
PharmGKB PA29634; -.
GeneCards P51553.
Gene expression databases
CleanEx HS_IDH3G; -.
GermOnline ENSG00000067829; Homo sapiens.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from experiment from Reactome).
GO:0004449; Molecular function: isocitrate dehydrogenase (NAD+) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0005975; Biological process: carbohydrate metabolic process (non-traceable author statement from ProtInc).
GO:0006102; Biological process: isocitrate metabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR004434; IsoCit_DHase_NAD_mit.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00175; mito_nad_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS P51553.
Genome annotation databases
Ensembl ENSG00000067829; Homo sapiens. [Contig view]
GeneID 3421; -.
KEGG hsa:3421; -.
Phylogenomic databases
HOGENOM P51553; -.
HOVERGEN P51553; -.
Other
DrugBank DB00157; NADH.
LinkHub P51553; -.
SOURCE IDH3G; Homo sapiens.
ProtoNet P51553.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Nucleotide-binding; Oxidoreductase; Phosphoprotein; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    39  39     Mitochondrion (By similarity). 
CHAIN   40   393  354     Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial. PRO_0000014449
NP_BIND   56    84  29     NAD (Potential). 
NP_BIND   309   316  8     ATP (Potential). 
METAL   254   254        Magnesium or manganese (By similarity). 
BINDING   136   136        Substrate (By similarity). 
BINDING   167   167        Substrate (By similarity). 
BINDING   254   254        Substrate (By similarity). 
SITE   174   174  1     Critical for catalysis (By similarity). 
SITE   221   221  1     Critical for catalysis (By similarity). 
MOD_RES   363   363        Phosphothreonine (By similarity). 
CONFLICT   267   267        F -> L (in Ref. 3; AAH01902). 
Sequence information
Length: 393 AA [This is the length of the unprocessed precursor] Molecular weight: 42794 Da [This is the MW of the unprocessed precursor] CRC64: A0870F2B7D228A37 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MALKVATVAG SAAKAVLGPA LLCRPWEVLG AHEVPSRNIF SEQTIPPSAK YGGRHTVTMI 

        70         80         90        100        110        120 
PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI RNAIMAIRRN RVALKGNIET 

       130        140        150        160        170        180 
NHNLPPSHKS RNNILRTSLD LYANVIHCKS LPGVVTRHKD IDILIVRENT EGEYSSLEHE 

       190        200        210        220        230        240 
SVAGVVESLK IITKAKSLRI AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA 

       250        260        270        280        290        300 
ARYPQITFEN MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 

       310        320        330        340        350        360 
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK AVLASMDNEN 

       370        380        390 
MHTPDIGGQG TTSEAIQDVI RHIRVINGRA VEA
P51553 in FASTA format

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