ID   CP7A1_RABIT             Reviewed;         501 AA.
AC   P51542;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-NOV-2008, entry version 51.
DE   RecName: Full=Cytochrome P450 7A1;
DE            EC=1.14.13.17;
DE   AltName: Full=CYPVII;
DE   AltName: Full=Cholesterol 7-alpha-monooxygenase;
DE   AltName: Full=Cholesterol 7-alpha-hydroxylase;
GN   Name=CYP7A1; Synonyms=CYP7;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Liver;
RX   MEDLINE=95271192; PubMed=7751825;
RA   Kai M., Eto T., Kondo K., Setoguchi Y., Higashi S., Maeda Y.,
RA   Setoguchi T.;
RT   "Synchronous circadian rhythms of mRNA levels and activities of
RT   cholesterol 7 alpha-hydroxylase in the rabbit and rat.";
RL   J. Lipid Res. 36:367-374(1995).
CC   -!- CATALYTIC ACTIVITY: Cholesterol + NADPH + O(2) = 7-alpha-
CC       hydroxycholesterol + NADP(+) + H(2)O.
CC   -!- COFACTOR: Heme group (By similarity).
CC   -!- PATHWAY: Lipid metabolism; bile acid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
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DR   EMBL; L10754; AAA74382.1; -; mRNA.
DR   PIR; I46701; I46701.
DR   HOVERGEN; P51542; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005792; C:microsome; IEA:UniProtKB-KW.
DR   GO; GO:0008123; F:cholesterol 7-alpha-monooxygenase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00465; EP450IV.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; Endoplasmic reticulum; Heme; Iron;
KW   Lipid metabolism; Membrane; Metal-binding; Microsome; Monooxygenase;
KW   NADP; Oxidoreductase; Steroid metabolism.
FT   CHAIN         1    501       Cytochrome P450 7A1.
FT                                /FTId=PRO_0000051904.
FT   METAL       441    441       Iron (heme axial ligand) (By similarity).
SQ   SEQUENCE   501 AA;  58090 MW;  FEF1247B151AA6B1 CRC64;
     MITIFWIWGI CLSVCCCLWL ILGLRRRRMG EPPLEKGWIP YLGCALQFGA NPLDFLRANQ
     RKYGHVFTCK LMGKYVHFIT NSLSYHKVLC HGKYFDWKKF HFTTSAKAFG HRSIDPRDGN
     TTENINNTFN KTLQGDALIS LTDAMMENLQ LTLRRPEPKS RAWVTEGMYS FCYRVMFEAG
     YLTLFGRELT RQDAQRAFIL NSLEDFKQFD KVFPALVAGL PIHIFMTAHN AREKLAEGLK
     HDNLRTRDHI SELIRLRMFL NDTLSTFDAM EKAKTHLAIL WASQANTIPA TFWSLFHMMR
     SSEALKAATE EVNKALEDAD QQINFEGKPI HLNQTQLNDM PVLDSIIKES LRLSSASLNI
     RTAKEDFTLH LEDGSYNIRK DDIIALYPQL MHLDPEIYPD PMTFKYDRYL DENRKTKTTF
     YSKGLKLKYY YMPFGSGATI CPGRLFAIQE IKQFLILMLS YFELEFVDSH VKCPPLDQSR
     AGLGILPPLN DIEFKYKFKH L
//