ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P51399

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name LOX5_MESAU
Primary accession number P51399
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 62)
Name and origin of the protein
Protein name Arachidonate 5-lipoxygenase
Synonyms 5-lipoxygenase
5-LO
EC 1.13.11.34
Gene name
Name: ALOX5
From
Mesocricetus auratus (Golden hamster) [TaxID: 10036] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Cricetidae; Cricetinae; Mesocricetus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Syrian;
DOI=10.1016/S0952-3278(96)90008-3; PubMed=8951996 [NCBI, ExPASy, EBI, Israel, Japan]
Kitzler J.W., Eling T.E.;
"Cloning, sequencing and expression of a 5-lipoxygenase from Syrian hamster embryo fibroblasts.";
Prostaglandins Leukot. Essent. Fatty Acids 55:269-277(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U43333; AAA85257.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P12530; 1LOX. [HSSP ENTRY / PDB]
ModBase P51399.
Family and domain databases
InterPro IPR000907; LipOase.
IPR013819; LipOase_C.
IPR001024; LipOase_LH2.
IPR001885; LipOase_mml.
Graphical view of domain structure.
Gene3D G3DSA:2.60.60.20; Lipase_LipOase; 1.
PANTHER PTHR11771; LipOase; 1.
Pfam PF00305; Lipoxygenase; 1.
PF01477; PLAT; 1.
Pfam graphical view of domain structure.
PRINTS PR00087; LIPOXYGENASE.
PR00467; MAMLPOXGNASE.
SMART SM00308; LH2; 1.
SMART graphical view of domain structure.
PROSITE PS00711; LIPOXYGENASE_1; 1.
PS00081; LIPOXYGENASE_2; 1.
PS51393; LIPOXYGENASE_3; 1.
PS50095; PLAT; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P51399.
Phylogenomic databases
HOVERGEN P51399; -.
Other
ProtoNet P51399.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Cytoplasm; Dioxygenase; Iron; Leukotriene biosynthesis; Membrane; Metal-binding; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   673  672     Arachidonate 5-lipoxygenase. PRO_0000220694
DOMAIN   2   117  116     PLAT. 
DOMAIN   118   673  556     Lipoxygenase. 
METAL   17    17        Calcium 1; via carbonyl oxygen; structural (By similarity). 
METAL   18    18        Calcium 2; via carbonyl oxygen; structural (By similarity). 
METAL   19    19        Calcium 2; structural (By similarity). 
METAL   44    44        Calcium 2; structural (By similarity). 
METAL   45    45        Calcium 2; via carbonyl oxygen; structural (By similarity). 
METAL   47    47        Calcium 2; structural (By similarity). 
METAL   79    79        Calcium 1; via carbonyl oxygen; structural (By similarity). 
METAL   80    80        Calcium 1; via carbonyl oxygen; structural (By similarity). 
METAL   367   367        Iron; catalytic (By similarity). 
METAL   372   372        Iron; catalytic (By similarity). 
METAL   550   550        Iron; catalytic (By similarity). 
METAL   554   554        Iron; catalytic (By similarity). 
METAL   673   673        Iron; via carboxylate; catalytic (By similarity). 
MOD_RES   271   271        Phosphoserine (By similarity). 
MOD_RES   523   523        Phosphoserine (By similarity). 
Sequence information
Length: 673 AA [This is the length of the unprocessed precursor] Molecular weight: 77873 Da [This is the MW of the unprocessed precursor] CRC64: A7AF63B11CDC7972 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPSYTVTVAT GSQWFAGTDD YIYLSLIGSA GCSEKHLLDK AFYNDFERGA VDSYDVTVDE 

        70         80         90        100        110        120 
ELGEIQLVRI EKRKYWLHDD WYLKYITLKT PTDYIEFPCY RWITGEGEIV LRDGRAKLAR 

       130        140        150        160        170        180 
DDQIHILKQH RRKELEARQK QYRWMEWNPG FPLSIDAKCH KDLPRDIQFD SEKGVDFVLN 

       190        200        210        220        230        240 
YSKAMENLFI NRFMHMFQSS WNDFADFEKI FVKISNTISE RVKNHWQEDL MFGYQFLNGC 

       250        260        270        280        290        300 
NPVLIKRCRE LPQKLPVTTE MVECSLERHL SLEQEVQEGN IFIVDYELLD GIDANKTDPC 

       310        320        330        340        350        360 
THQFLAAPIC LLYKNLANKI VPIAIQLNQA PGEKNPIFLP SDAKYDWLLA KIWVRSSDFH 

       370        380        390        400        410        420 
VHQTITHLLC THLVSEVFGI AMYRQLPAVH PIFKLLVAHV RFTIAINTKA REQLICEYGL 

       430        440        450        460        470        480 
FDKANATGGG GHVQMVQRAV QDLTYSSLCF PEAIKARGMD STEDIPYYFY RDDGLLVWEA 

       490        500        510        520        530        540 
IQSFTSEVVS IYYEDDQVVM EDQELQDFVK DVYVYGMRGR KASGFPKSIK SREKLSEYLT 

       550        560        570        580        590        600 
VVIFTASAQH AAVNFGQYDW CSWIPNAPPT MRAPPATAKG VVTIEQIVAT LPDRGRSCWH 

       610        620        630        640        650        660 
LGAVWALSQF QENELFLGMY PEEHFIEKPV KEAMTRFRKN LEAIVNVIAE RNKNKKLPYY 

       670 
YLSPDRIPNS VAI
P51399 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by kr flag YPRC Korea Mirror sites: Australia Brazil Canada China Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!