[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=Avonport; Reith M.E., Munholland J.; "Complete nucleotide sequence of the Porphyra purpurea chloroplast genome."; Plant Mol. Biol. Rep. 13:333-335(1995).

Comments

FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate.
SUBUNIT: Heterodimer of an alpha and a beta chain (By similarity).
SUBCELLULAR LOCATION: Plastid, chloroplast.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U38804; AAC08152.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S73187; S73187.

RefSeq

NP_053876.1; -.

3D structure databases

HSSP

Q8ZUR7; 1IK6. [HSSP ENTRY / PDB]

ModBase

P51266.

Ontologies

GO:0009507;	Cellular component: chloroplast (inferred from electronic annotation from UniProtKB-KW).
GO:0004739;	Molecular function: pyruvate dehydrogenase (acetyl-transferring) activity (inferred from electronic annotation from EC).
GO:0006096;	Biological process: glycolysis (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR005476; Transketo_C.
IPR005475; Transketo_Cen_R.
IPR015941; Transketolase_C-like.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.920; Transketo_C_like; 1.

Pfam

PF02779; Transket_pyr; 1.
PF02780; Transketolase_C; 1.
Pfam graphical view of domain structure.

Genome annotation databases

GeneID

809895; -.

Other

ProtoNet

P51266.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Chloroplast; Glycolysis; Oxidoreductase; Plastid; Pyruvate; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 331`	`331`	`Pyruvate dehydrogenase E1 component subunit beta.`	`PRO_0000162219`
`BINDING`	`60 60`		`Thiamine pyrophosphate (By similarity).`

Sequence information

Length: 331 AA [This is the length of the unprocessed precursor]

Molecular weight: 36394 Da [This is the MW of the unprocessed precursor]

CRC64: 12D1B9467D4DC993 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSKVFMFDAL RAATDEEMEK DLTVCVIGED VGHYGGSYKV TKDLHSKYGD LRVLDTPIAE 

        70         80         90        100        110        120 
NSFTGMAIGA AITGLRPIVE GMNMSFLLLA FNQISNNAGM LRYTSGGNFT LPLVIRGPGG 

       130        140        150        160        170        180 
VGRQLGAEHS QRLEAYFQAI PGLKIVACST PYNAKGLLKS AIRDNNPVVF FEHVLLYNLQ 

       190        200        210        220        230        240 
EEIPEDEYLI PLDKAEVVRK GKDITILTYS RMRHHVTEAL PLLLNDGYDP EVLDLISLKP 

       250        260        270        280        290        300 
LDIDSISVSV KKTHRVLIVE ECMKTAGIGA ELIAQINEHL FDELDAPVVR LSSQDIPTPY 

       310        320        330 
NGSLEQATVI QPHQIIDAVK NIVNSSKTIT T

P51266 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools