NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=NCIMB 9816;
PubMed=7496535 [NCBI, ExPASy, EBI, Israel, Japan]
Platt A., Shingler V., Taylor S.C., Williams P.A.;
"The 4-hydroxy-2-oxovalerate aldolase and acetaldehyde dehydrogenase (acylating) encoded by the nahM and nahO genes of the naphthalene catabolic plasmid pWW60-22 provide further evidence of conservation of meta-cleavage pathway gene sequences.";
Microbiology 141:2223-2233(1995).

Comments

FUNCTION: Catalyzes the production of pyruvate and acetaldehyde from 4-hydroxy-2-oxovalerate.
CATALYTIC ACTIVITY: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.
PATHWAY: Aromatic compound metabolism; salicylic acid degradation .

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U13232; AAA89107.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_863098.1; -.

3D structure databases

HSSP

P51016; 1NVM. [HSSP ENTRY / PDB]

ModBase

P51017.

Ontologies

GO:0008701;	Molecular function: 4-hydroxy-2-oxovalerate aldolase activity (inferred from electronic annotation from InterPro).
GO:0019439;	Biological process: aromatic compound catabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR017629; 4OH_2_O-val_aldolase.
IPR013785; Aldolase_TIM.
IPR012425; DmpG_comm.
IPR000891; PYR_CT.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

Pfam

PF07836; DmpG_comm; 1.
PF00682; HMGL-like; 1.
Pfam graphical view of domain structure.

PROSITE

PS50991; PYR_CT; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

1343200; -.

Other

ProtoNet

P51017.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aromatic hydrocarbons catabolism; Lyase; Plasmid.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 346`	`346`		`4-hydroxy-2-oxovalerate aldolase.`	`PRO_0000096706`

Sequence information

Length: 346 AA [This is the length of the unprocessed precursor]

Molecular weight: 37102 Da [This is the MW of the unprocessed precursor]

CRC64: 65963EE93E4BAB7F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNLHGKSVIL HDMSLRDGMH AKRHQISLEQ MVAVATGLDQ AGMPLIEITH GDGLGGRSIN 

        70         80         90        100        110        120 
YGFPAHSDEE YLRAVIPQLK QAKVSALLLP GIGTVDHLKM ALDCGVSTIR VATHCTEADV 

       130        140        150        160        170        180 
SEQHIGMARK LGVDTVGFLM MAHMISAEKV LEQAKLMESY GANCIYCTDS AGYMLPDEVS 

       190        200        210        220        230        240 
EKIGLLRAEL NPATEVGFHG HHNMGMAIAN SLAAIEAGAA RIDGSVAGLG AGAGNTPLEV 

       250        260        270        280        290        300 
FVAVCKRMGV ETGIDLYKIM DVAEDLVVPM MDQPIRVDRD ALTLGYAGVY SSFLLFAQRA 

       310        320        330        340 
EKKYGVSARD ILVELGRRGT VGGQEDMIED LALDMARARQ QQKVSA

P51017 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools