ID   LDHD_LEUMC              Reviewed;         331 AA.
AC   P51011;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-NOV-2008, entry version 50.
DE   RecName: Full=D-lactate dehydrogenase;
DE            Short=D-LDH;
DE            EC=1.1.1.28;
DE   AltName: Full=D-specific D-2-hydroxyacid dehydrogenase;
OS   Leuconostoc mesenteroides subsp. cremoris.
OC   Bacteria; Firmicutes; Lactobacillales; Leuconostoc.
OX   NCBI_TaxID=33965;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=195;
RX   MEDLINE=96008867; PubMed=7569323; DOI=10.1016/0923-2508(96)81052-7;
RA   Dartois V., Phalip V., Schmitt P., Divies C.;
RT   "Purification, properties and DNA sequence of the D-lactate
RT   dehydrogenase from Leuconostoc mesenteroides subsp. cremoris.";
RL   Res. Microbiol. 146:291-302(1995).
CC   -!- CATALYTIC ACTIVITY: (R)-lactate + NAD(+) = pyruvate + NADH.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family.
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DR   EMBL; L29327; AAA99506.1; -; Genomic_DNA.
DR   HSSP; P30901; 2DLD.
DR   BioCyc; MetaCyc:MON-13061; -.
DR   GO; GO:0008720; F:D-lactate dehydrogenase activity; IEA:EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006139; D-isomer_2_OHA_DHase.
DR   InterPro; IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; FALSE_NEG.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN         1    331       D-lactate dehydrogenase.
FT                                /FTId=PRO_0000075957.
FT   ACT_SITE    235    235       By similarity.
FT   ACT_SITE    264    264       By similarity.
FT   ACT_SITE    296    296       Proton donor (By similarity).
SQ   SEQUENCE   331 AA;  36316 MW;  0A63C462303672D8 CRC64;
     MKIFAYGIRD DEKPSLEEWK AANPEIEVDY TQELLTPETA KLAEGSDSAV VYQQLDYTRE
     TLTALANVGV TNLSLRNVGT DNIDFDAARE FNFNISNVPV YSPNAIAEHS MLQLSRLLRR
     TKALDAKIAK RDLRWAPTTG REMRMQTVGV IGTGHIGRVA INILKGFGAK VIAYDKYPNA
     ELQAEGLYVD TLDELYAQAD AISLYVPGVP ENHHLINADA IAKMKDGVVI MNAARGNLMD
     IDAIIDGLNS GKISDFGMDV YENEVACSMK IGLVKNSPDA KIADLIAREN VMITPHTAFY
     TTKAVLEMVH QSFDAAVAFA KGEKPAIAVE Y
//