[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Testis; PubMed=7657834 [NCBI, ExPASy, EBI, Israel, Japan] Ogawa Y., Masuzaki H., Isse N., Okazaki T., Mori K., Shigemoto M., Satoh N., Tamura N., Hosoda K., Yoshimasa Y., Jingami H., Kawada T., Nakao K.; "Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats."; J. Clin. Invest. 96:1647-1652(1995).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Sprague-Dawley; TISSUE=Adipose tissue; DOI=10.1006/bbrc.1995.1837; PubMed=7794258 [NCBI, ExPASy, EBI, Israel, Japan] Funahashi T., Shimomura I., Hiraoka H., Arai T., Takahashi M., Nakamura T., Nozaki S., Yamashita S., Takemura K., Tokunaga K.; "Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats."; Biochem. Biophys. Res. Commun. 211:469-475(1995).
[3]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=Leto, OLETF, and Zucker; TISSUE=Adipose tissue; DOI=10.1006/bbrc.1995.1589; PubMed=7733988 [NCBI, ExPASy, EBI, Israel, Japan] Murakami T., Shima K.; "Cloning of rat obese cDNA and its expression in obese rats."; Biochem. Biophys. Res. Commun. 209:944-952(1995).
[4]	NUCLEOTIDE SEQUENCE [MRNA] OF 14-167. STRAIN=Sprague-Dawley; TISSUE=Adipose tissue; Donohoue P.A., Sivitz W.I., Bailey H.L.; Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of Lep may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
SUBCELLULAR LOCATION: Secreted (Probable).
SIMILARITY: Belongs to the leptin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D45862; BAA08296.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S78586; AAB34657.2; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
D49653; BAA08529.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U48849; AAC52514.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PC4034; LTRT.

NP_037208.1; -.

3D structure databases

HSSP

P41159; 1AX8. [HSSP ENTRY / PDB]

SMR

P50596; 24-167.

ModBase

P50596.

Organism-specific databases

RGD

3000; Lep.

Gene expression databases

ArrayExpress

P50596; -.

GermOnline

ENSRNOG00000006059; Rattus norvegicus.

Ontologies

GO:0005615;	Cellular component: extracellular space (inferred from direct assay from HGNC).
GO:0005179;	Molecular function: hormone activity (inferred from electronic annotation from InterPro).
GO:0008343;	Biological process: adult feeding behavior (inferred from sequence or structural similarity from HGNC).
GO:0032099;	Biological process: negative regulation of appetite (inferred from sequence or structural similarity from HGNC).
GO:0007165;	Biological process: signal transduction (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR012351; 4_helix_cytokine_core.
IPR000065; Leptin.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.

PANTHER

PTHR11724; Leptin; 1.

Pfam

PF02024; Leptin; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001837; Leptin; 1.

PRINTS

PR00495; LEPTIN.

ProDom

PD005698; Leptin; 1.
[Domain structure / List of seq. sharing at least 1 domain]

Genome annotation databases

Ensembl

ENSRNOG00000006059; Rattus norvegicus. [Contig view]

GeneID

25608; -.

KEGG

rno:25608; -.

Phylogenomic databases

HOVERGEN

P50596; -.

Other

607339; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Obesity; Secreted; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 21`	`21`	`Potential.`
`CHAIN`	`22 167`	`146`	`Leptin.`	`PRO_0000017690`
`DISULFID`	`117 167`		`By similarity.`
`CONFLICT`	`32 32`		`K -> T (in Ref. 2).`
`CONFLICT`	`163 163`		`L -> V (in Ref. 4; AAC52514).`

Sequence information

Length: 167 AA [This is the length of the unprocessed precursor]

Molecular weight: 18866 Da [This is the MW of the unprocessed precursor]

CRC64: 3B5B563DA42EC84E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MCWRPLCRFL WLWSYLSYVQ AVPIHKVQDD TKTLIKTIVT RINDISHTQS VSARQRVTGL 

        70         80         90        100        110        120 
DFIPGLHPIL SLSKMDQTLA VYQQILTSLP SQNVLQIAHD LENLRDLLHL LAFSKSCSLP 

       130        140        150        160 
QTRGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDLSPEC

P50596 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools