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UniProtKB/Swiss-Prot entry P50529

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name STHA_VIBCH
Primary accession number P50529
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on December 1, 2000 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name Soluble pyridine nucleotide transhydrogenase
Synonyms STH
EC 1.6.1.1
NAD(P)(+) transhydrogenase [B-specific]
Gene name
Name: sthA
Synonyms: udhA
OrderedLocusNames: VC_0151
From
Vibrio cholerae [TaxID: 666] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 39315 / El Tor Inaba N16961 / Serotype O1;
DOI=10.1038/35020000; PubMed=10952301 [NCBI, ExPASy, EBI, Israel, Japan]
Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.";
Nature 406:477-483(2000).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 421-466.
STRAIN=ATCC 25870 / Classical Inaba 569B / Serotype O1;
DOI=10.1016/S0378-1119(96)00849-9; PubMed=9168128 [NCBI, ExPASy, EBI, Israel, Japan]
Sahu G.K., Chowdhury R., Das J.;
"The rpoH gene encoding sigma 32 homolog of Vibrio cholerae.";
Gene 189:203-207(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE003852; AAF93328.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U44432; AAC45342.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E82357; E82357.
RefSeq NP_229809.1; -.
3D structure databases
HSSP P18925; 3LAD. [HSSP ENTRY / PDB]
ModBase P50529.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003957; Molecular function: NAD(P)+ transhydrogenase (B-specific) activity (inferred from electronic annotation from HAMAP).
GO:0006739; Biological process: NADP metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00247; -; 1.
PBIL [Tree]
InterPro IPR000759; Adrndx_reductase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000815; Hg_reductase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR001327; Pyr_OxRdtase_NAD_bd.
IPR003042; Rng_hydrolase.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00945; HGRDTASE.
PR00411; PNDRDTASEI.
PR00420; RNGMNOXGNASE.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS P50529.
Genome annotation databases
GeneID 2614850; -.
GenomeReviews AE003852_GR; VC_0151.
KEGG vch:VC0151; -.
TIGR VC_0151; -.
Phylogenomic databases
HOGENOM P50529; -.
Other
ProtoNet P50529.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; FAD; Flavoprotein; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   466  466     Soluble pyridine nucleotide transhydrogenase. PRO_0000068075
NP_BIND   36    45  10     FAD (By similarity). 
Sequence information
Length: 466 AA [This is the length of the unprocessed precursor] Molecular weight: 50942 Da [This is the MW of the unprocessed precursor] CRC64: 60D05DB3FD595BE1 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGQKNHFDVI VIGSGPGGEG AAMGLTKGGK NVAIIEKESS VGGGCTHWGT IPSKALRHAV 

        70         80         90        100        110        120 
SRIIEFNSNP LFCKNNSSIH ATFSTILSHA KSVIDKQTRL RQGFYDRNQC TLIFGAAHFI 

       130        140        150        160        170        180 
DAHTVAVKKA DGSIDTYSAD KFVIATGSRP YHPKDVDFGH PRIYDSDSIL NLEHDPRHII 

       190        200        210        220        230        240 
IYGAGVIGCE YASIFRGLDV KTDLINTRDR LLSFLDNEVS DALSYHFWNS GVVIRNDETY 

       250        260        270        280        290        300 
DKVEGTSDGV IVHLKSGKKM RADCLLYANG RTGNTDKLNL ESVGLQADSR GQLVVNANYQ 

       310        320        330        340        350        360 
TQVEHIYAVG DVIGYPSLAS AAYDQGRFVA QAIIHGQAAH LLTEDIPTGI YTIPEISSVG 

       370        380        390        400        410        420 
RTEQELTAAK VPYEVGRASF KHLARAQIAG KDIGSLKILF HRETKEILGI HCFGERAAEI 

       430        440        450        460 
IHIGQAIMEQ KGEANTIEYF VNTTFNYPTM AEAFRVAALN GLNRLF
P50529 in FASTA format

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