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UniProtKB/Swiss-Prot entry P50217

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDHC_SOLTU
Primary accession number P50217
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 55)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: ICDH-1
From
Solanum tuberosum (Potato) [TaxID: 4113] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Desiree;
TISSUE=Leaf;
DOI=10.1104/pp.107.3.905; PubMed=7716247 [NCBI, ExPASy, EBI, Israel, Japan]
Fieuw S., Mueller-Roeber B., Galvez S., Willmitzer L.;
"Cloning and expression analysis of the cytosolic NADP(+)-dependent isocitrate dehydrogenase from potato. Implications for nitrogen metabolism.";
Plant Physiol. 107:905-913(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X75638; CAA53300.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S47013; S47013.
T07402; T07402.
3D structure databases
HSSP P33198; 1LWD. [HSSP ENTRY / PDB]
ModBase P50217.
Family and domain databases
InterPro IPR004790; IsoCit_DHase_NADP-dep_euk.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11822; IDH_NADP_euk; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000108; IDH_NADP; 1.
ProDom PD328597; Nadp_idh_plant; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00127; nadp_idh_euk; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS P50217.
Other
ProtoNet P50217.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   416  416     Isocitrate dehydrogenase [NADP]. PRO_0000083584
NP_BIND   77    79  3     NADP (By similarity). 
NP_BIND   312   317  6     NADP (By similarity). 
REGION   96   102  7     Substrate binding (By similarity). 
METAL   254   254        Magnesium or manganese (By similarity). 
METAL   277   277        Magnesium or manganese (By similarity). 
BINDING   79    79        Substrate (By similarity). 
BINDING   84    84        NADP (By similarity). 
BINDING   111   111        Substrate (By similarity). 
BINDING   134   134        Substrate (By similarity). 
BINDING   262   262        NADP (By similarity). 
BINDING   330   330        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
SITE   141   141  1     Critical for catalysis (By similarity). 
SITE   214   214  1     Critical for catalysis (By similarity). 
Sequence information
Length: 416 AA [This is the length of the unprocessed precursor] Molecular weight: 46792 Da [This is the MW of the unprocessed precursor] CRC64: B9A9D6AD53AB090D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAFQKITVQN PIVEMDGDEM TRVIWKSIKD KLILPFLELD IKYFSLGLPH RDATDDKVTV 

        70         80         90        100        110        120 
ESAEATQKYN VAIKCATITP DEARVKEFNL KSMWRSPNGT IRNILNGTVF REPIMCKNIP 

       130        140        150        160        170        180 
RLVPGWTKPI CIGRHAFGDQ YRATDTVIKG AGKLKLVFVP EGSDEKTEFE VYNFTGAGGV 

       190        200        210        220        230        240 
ALSMYNTDES VRSFAEASMN MAFQKKWPLY LSTKNTILKK YDGRFKDIFQ EVYEANWKSK 

       250        260        270        280        290        300 
YEEAGIWYEH RLIDDMVAYA LKSEGGYVWA CKNYDGDVQS DFLAQGFGSL GLMTSVLVCP 

       310        320        330        340        350        360 
DGKTIEAEAA HGTVTRHYRV HQKGGETSTN SIASIFAWTR GLAHRATLDN NERLLDFTEK 

       370        380        390        400        410 
LEAACIGAVE SGKMTKDLAL IIIHGSKLSR EHYLNTEEFI DAVADELKAR LLKAKA
P50217 in FASTA format

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