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UniProtKB/Swiss-Prot entry P49602


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP51_USTMA
Primary accession number P49602
Secondary accession number Q4P8A1
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 1, 1996 (Sequence version 1)
Annotations were last modified on    October 14, 2008 (Entry version 50)
Name and origin of the protein
Protein name Cytochrome P450 51
Synonyms EC 1.14.13.70
CYPLI
P450-LIA1
Sterol 14-alpha demethylase
Lanosterol 14-alpha demethylase
P450-14DM
Gene name
Name: ERG11
Synonyms: CYP51
ORFNames: UM03662
From
Ustilago maydis (Smut fungus) [TaxID: 5270] 
Taxonomy Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina; Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=IMI 103761;
DOI=10.1016/0378-1097(96)00142-5; PubMed=8674989 [NCBI, ExPASy, EBI, Israel, Japan]
Hargreaves J.A., Keon J.P.R.;
"Isolation of an Ustilago maydis ERG11 gene and its expression in a mutant deficient in sterol 14 alpha-demethylase activity.";
FEMS Microbiol. Lett. 139:203-207(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=521;
DOI=10.1038/nature05248; PubMed=17080091 [NCBI, ExPASy, EBI, Israel, Japan]
Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.;
"Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis.";
Nature 444:97-101(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z48164; CAA88176.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AACP01000124; EAK84840.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S52319; S52319.
RefSeq XP_759809.1; -.
3D structure databases
HSSP P77901; 1E9X. [HSSP ENTRY / PDB]
ModBase P49602.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002403; Cyt_P450_E_grp-IV.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00465; EP450IV.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS P49602.
Genome annotation databases
GeneID 3631809; -.
KEGG uma:UM03662.1; -.
Other
ProtoNet P49602.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Heme; Iron; Lipid synthesis; Membrane; Metal-binding; Monooxygenase; NADP; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   561  561     Cytochrome P450 51. PRO_0000052011
METAL   501   501        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 561 AA [This is the length of the unprocessed precursor] Molecular weight: 62197 Da [This is the MW of the unprocessed precursor] CRC64: 2F9A6647D9B17FB0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MVASSSSATA SLLDQLFALT PLADSSAWIK TITVLVLLPL LAVVLNVASQ LLLATPKNHP 

        70         80         90        100        110        120 
PVVFHFVPVI GSAIYYGIDP YKFFFECREK YGDVFTFVLL GRKITVALGP KGSNLVFNAK 

       130        140        150        160        170        180 
HQQVTAEDAY THLTTPVFGK EVVYDVPNAV FMEQKKFVKV GLSIENFRVY VPQIVDEVRE 

       190        200        210        220        230        240 
YIKSDARFSA LKTRKTITVD IFQAMSELII LTASRTLQGK EVRQGLDKSF AQLYHDLDSG 

       250        260        270        280        290        300 
FTPINFVIPN LPLPSNFKRD RAQKKMSQFY QDIVAKRRAA GASTSADDAS GENDMIAALI 

       310        320        330        340        350        360 
EQKYKNGRAL SGVEIAHMMI ALLMAGQHTS SATSSWAFLR LASRPEIIEE LYEEQLNVYS 

       370        380        390        400        410        420 
DGHGGLRELD YETQKTSVPL LDAVVKETLR LHPPLHSIMR YVKSDLAVPP TLSSPTSTKS 

       430        440        450        460        470        480 
EPDAHYVIPK GHYIMAAPGV SQVDPQIWKS SDQFDPHRWL DATTAAAMQD SGEDKQDFGF 

       490        500        510        520        530        540 
GMISTGANSP YLPFGAGRHR CIGEQFAYLQ IGVILATFVR IFKWHLDSKF PDPDYQSMVV 

       550        560 
LPSKNGCAIV LTPRAESLHL D 

P49602 in FASTA format

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