ID   FMO1_CAVPO              Reviewed;          19 AA.
AC   P49328;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-NOV-2008, entry version 39.
DE   RecName: Full=Dimethylaniline monooxygenase [N-oxide-forming] 1;
DE            EC=1.14.13.8;
DE   AltName: Full=Hepatic flavin-containing monooxygenase 1;
DE            Short=FMO 1;
DE   AltName: Full=Dimethylaniline oxidase 1;
DE   Flags: Fragment;
GN   Name=FMO1; Synonyms=FMO-1;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RX   MEDLINE=90314396; PubMed=2369122; DOI=10.1016/0003-9861(90)90334-U;
RA   Yamada H., Yuno K., Oguri K., Yoshimura H.;
RT   "Multiplicity of liver microsomal flavin-containing monooxygenase in
RT   the guinea pig: its purification and characterization.";
RL   Arch. Biochem. Biophys. 280:305-312(1990).
CC   -!- FUNCTION: This protein is involved in the oxidative metabolism of
CC       a variety of xenobiotics such as drugs and pesticides.
CC   -!- CATALYTIC ACTIVITY: N,N-dimethylaniline + NADPH + O(2) = N,N-
CC       dimethylaniline N-oxide + NADP(+) + H(2)O.
CC   -!- COFACTOR: FAD.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane. Endoplasmic reticulum
CC       membrane.
CC   -!- TISSUE SPECIFICITY: Liver.
CC   -!- SIMILARITY: Belongs to the FMO family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   PIR; S10747; S10747.
DR   HOVERGEN; P49328; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005792; C:microsome; IEA:UniProtKB-KW.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0004499; F:flavin-containing monooxygenase activity; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000960; Flavin_mOase.
DR   Pfam; PF00743; FMO-like; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Endoplasmic reticulum; FAD; Flavoprotein;
KW   Membrane; Microsome; Monooxygenase; NADP; Oxidoreductase;
KW   Transmembrane.
FT   CHAIN         1    >19       Dimethylaniline monooxygenase [N-oxide-
FT                                forming] 1.
FT                                /FTId=PRO_0000147638.
FT   NON_TER      19     19
SQ   SEQUENCE   19 AA;  1826 MW;  324DDEB75CA05522 CRC64;
     VKKVAIIGAG VSGLASIRS
//