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UniProtKB/Swiss-Prot entry P49109

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FMO5_CAVPO
Primary accession number P49109
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name Dimethylaniline monooxygenase [N-oxide-forming] 5
Synonyms EC 1.14.13.8
Hepatic flavin-containing monooxygenase 5
FMO 5
Dimethylaniline oxidase 5
Gene name
Name: FMO5
From
Cavia porcellus (Guinea pig) [TaxID: 10141] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricognathi; Caviidae; Cavia.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Hartley;
TISSUE=Liver;
DOI=10.1006/abbi.1995.1163; PubMed=7872795 [NCBI, ExPASy, EBI, Israel, Japan]
Overby L.H., Buckpitt A.R., Lawton M.P., Atta-Asafo-Adjei E., Schulze J., Philpot R.M.;
"Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog.";
Arch. Biochem. Biophys. 317:275-284(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L37081; AAA67848.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S71617; S71617.
3D structure databases
ModBase P49109.
Family and domain databases
InterPro IPR012143; dManiline_mOase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000960; Flavin_mOase.
IPR002257; Flavin_mOase_5.
Graphical view of domain structure.
Pfam PF00743; FMO-like; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000332; FMO; 1.
PRINTS PR00368; FADPNR.
PR00370; FMOXYGENASE.
PR01125; FMOXYGENASE5.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS P49109.
Phylogenomic databases
HOVERGEN P49109; -.
Other
ProtoNet P49109.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Methylation; Microsome; Monooxygenase; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   533  532     Dimethylaniline monooxygenase [N-oxide-forming] 5. PRO_0000147664
NP_BIND   10    15  6     FAD (Potential). 
NP_BIND   192   197  6     NADP (By similarity). 
MOD_RES   2     2        N-acetylthreonine (By similarity). 
MOD_RES   5     5        Omega-N-methylated arginine (By similarity). 
Sequence information
Length: 533 AA [This is the length of the unprocessed precursor] Molecular weight: 60125 Da [This is the MW of the unprocessed precursor] CRC64: E0C06EE4C6B6EFDD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTKKRIAVIG GGVSGLSSIK CCLEEGLEPV CFERSADIGG LWRFQENPEE GRASIYKSVI 

        70         80         90        100        110        120 
INTSKEMMCF SDYPIPDHYP NFMHNSHVLE YFRMYAKEFG LLKYIQFKTT VCNVKKRPDF 

       130        140        150        160        170        180 
STSGQWEVVT EHEGKTKVDV FDAVMVCTGH HTNAHLPLES FPGIEKFKGQ YFHSRDYKNP 

       190        200        210        220        230        240 
EAFTGKRVVI IGIGNSGGDL AVEISHTAKQ VFLSTRRGSW ILNRVGKHGY PTDVLLSSRF 

       250        260        270        280        290        300 
TYFLSKILGQ SLSNAYVEKQ MNERFDHEMF GLKPKHRAMS QHPTVNDDLP NRIIAGMVKV 

       310        320        330        340        350        360 
KGNVKEFTET AAIFEDGSRE DDIDAVIFAT GYSFDFPFLE DSVKVVKNKV SLYKKVFPPN 

       370        380        390        400        410        420 
LERPTLAIIG LIQPLGAIMP ISELQGRWAV QVFKGLKTLP SQSEMMAEIT KAQEEIAKRY 

       430        440        450        460        470        480 
VDSQRHTIQG DYIQTMEEIA EFVGVKPNLL SLAFTDPKLA LKLFFGPCTP IHYRLQGPGK 

       490        500        510        520        530 
WHGARKAILT TYDRIRKPLN TRETEKSNSM VSAVTTGCFM LAVVFFAIIM AYA
P49109 in FASTA format

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