ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P48999

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name LOX5_MOUSE
Primary accession number P48999
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 68)
Name and origin of the protein
Protein name Arachidonate 5-lipoxygenase
Synonyms 5-lipoxygenase
5-LO
EC 1.13.11.34
Gene name
Name: Alox5
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6 X 129/Sv;
TISSUE=Peritoneal cavity;
DOI=10.1074/jbc.270.30.17993; PubMed=7629107 [NCBI, ExPASy, EBI, Israel, Japan]
Chen X.-S., Naumann T.A., Kurre U., Jenkins N.A., Copeland N.G., Funk C.D.;
"cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase.";
J. Biol. Chem. 270:17993-17999(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42198; AAC37673.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I49479; I49479.
UniGene Mm.41072
3D structure databases
HSSP P12530; 1LOX. [HSSP ENTRY / PDB]
ModBase P48999.
PTM databases
PhosphoSite P48999; -.
Organism-specific databases
MGI MGI:87999; Alox5.
Gene expression databases
ArrayExpress P48999; -.
CleanEx MM_ALOX5; -.
GermOnline ENSMUSG00000025701; Mus musculus.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from MGI).
GO:0005634; Cellular component: nucleus (inferred from direct assay from MGI).
GO:0006954; Biological process: inflammatory response (inferred from mutant phenotype from MGI).
GO:0006691; Biological process: leukotriene metabolic process (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR000907; LipOase.
IPR013819; LipOase_C.
IPR001024; LipOase_LH2.
IPR001885; LipOase_mml.
Graphical view of domain structure.
Gene3D G3DSA:2.60.60.20; Lipase_LipOase; 1.
PANTHER PTHR11771; LipOase; 1.
Pfam PF00305; Lipoxygenase; 1.
PF01477; PLAT; 1.
Pfam graphical view of domain structure.
PRINTS PR00087; LIPOXYGENASE.
PR00467; MAMLPOXGNASE.
SMART SM00308; LH2; 1.
SMART graphical view of domain structure.
PROSITE PS00711; LIPOXYGENASE_1; 1.
PS00081; LIPOXYGENASE_2; 1.
PS51393; LIPOXYGENASE_3; 1.
PS50095; PLAT; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P48999.
Genome annotation databases
Ensembl ENSMUSG00000025701; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM P48999; -.
HOVERGEN P48999; -.
Other
SOURCE Alox5; Mus musculus.
ProtoNet P48999.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Cytoplasm; Dioxygenase; Iron; Leukotriene biosynthesis; Membrane; Metal-binding; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   674  673     Arachidonate 5-lipoxygenase. PRO_0000220695
DOMAIN   2   118  117     PLAT. 
DOMAIN   119   674  556     Lipoxygenase. 
METAL   17    17        Calcium 1; via carbonyl oxygen; structural (By similarity). 
METAL   18    18        Calcium 2; via carbonyl oxygen; structural (By similarity). 
METAL   19    19        Calcium 2; structural (By similarity). 
METAL   44    44        Calcium 2; structural (By similarity). 
METAL   45    45        Calcium 2; via carbonyl oxygen; structural (By similarity). 
METAL   47    47        Calcium 2; structural (By similarity). 
METAL   79    79        Calcium 1; via carbonyl oxygen; structural (By similarity). 
METAL   80    80        Calcium 1; via carbonyl oxygen; structural (By similarity). 
METAL   368   368        Iron; catalytic (By similarity). 
METAL   373   373        Iron; catalytic (By similarity). 
METAL   551   551        Iron; catalytic (By similarity). 
METAL   555   555        Iron; catalytic (By similarity). 
METAL   674   674        Iron; via carboxylate; catalytic (By similarity). 
MOD_RES   272   272        Phosphoserine (By similarity). 
MOD_RES   524   524        Phosphoserine (By similarity). 
Sequence information
Length: 674 AA [This is the length of the unprocessed precursor] Molecular weight: 77999 Da [This is the MW of the unprocessed precursor] CRC64: 4061CD107EE53B4F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPSYTVTVAT GSQWFAGTDD YIYLSLIGSA GCSEKHLLDK AFYNDFERGA VDSYDVTVDE 

        70         80         90        100        110        120 
ELGEIYLVKI EKRKYWLHDD WYLKYITLKT PHGDYIEFPC YRWITGEGEI VLRDGRAKLA 

       130        140        150        160        170        180 
RDDQIHILKQ HRRKELEARQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL 

       190        200        210        220        230        240 
NYSKAMENLF INRFMHMFQS SWHDFADFEK IFVKISNTIS ERVKNHWQED LMFGYQFLNG 

       250        260        270        280        290        300 
CNPVLIKRCT ALPPKLPVTT EMVECSLERQ LSLEQEVQEG NIFIVDYELL DGIDANKTDP 

       310        320        330        340        350        360 
CTHQFLAAPI CLLYKNLANK IVPIAIQLNQ TPGESNPIFL PTDSKYDWLL AKIWVRSSDF 

       370        380        390        400        410        420 
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPLFKLLVAH VRFTIAINTK AREQLICEYG 

       430        440        450        460        470        480 
LFDKANATGG GGHVQMVQRA VQDLTYSSLC FPEAIKARGM DSTEDMPFYF YRDDGLLVWE 

       490        500        510        520        530        540 
AIQSFTMEVV SIYYENDQVV EEDQELQDFV KDVYVYGMRG KKASGFPKSI KSREKLSEYL 

       550        560        570        580        590        600 
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW 

       610        620        630        640        650        660 
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMIRFRK NLEAIISVIA ERNKNKKLPY 

       670 
YYLSPDRIPN SVAI
P48999 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by kr flag YPRC Korea Mirror sites: Australia Brazil Canada China Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!