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UniProtKB/Swiss-Prot entry P48735

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDHP_HUMAN
Primary accession number P48735
Secondary accession number Q96GT3
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on April 3, 2002 (Sequence version 2)
Annotations were last modified on    September 23, 2008 (Entry version 80)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP], mitochondrial [Precursor]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
ICD-M
Gene name
Name: IDH2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
Huh T.-L., Oh I.-U., Kim Y.O., Huh J.-W., Song B.J.;
Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X69433; CAA49208.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009244; AAH09244.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC071828; AAH71828.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S57499; S57499.
RefSeq NP_002159.2; -.
UniGene Hs.596461
3D structure databases
HSSP P33198; 1LWD. [HSSP ENTRY / PDB]
SMR P48735; 40-452.
ModBase P48735.
2D gel databases
OGP P48735; -.
Organism-specific databases
HGNC HGNC:5383; IDH2.
GenAtlas IDH2.
MIM 147650; gene. [NCBI / EBI]
PharmGKB PA29631; -.
GeneCards P48735.
Gene expression databases
ArrayExpress P48735; -.
CleanEx HS_IDH2; -.
GermOnline ENSG00000182054; Homo sapiens.
Ontologies
GO
GO:0005975; Biological process: carbohydrate metabolic process (non-traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR004790; IsoCit_DHase_NADP-dep_euk.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11822; IDH_NADP_euk; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000108; IDH_NADP; 1.
TIGRFAMs TIGR00127; nadp_idh_euk; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS P48735.
Proteomic databases
PeptideAtlas P48735; -.
Genome annotation databases
Ensembl ENSG00000182054; Homo sapiens. [Contig view]
GeneID 3418; -.
KEGG hsa:3418; -.
NMPDR fig|9606.3.peg.11234; -.
Phylogenomic databases
HOGENOM P48735; -.
HOVERGEN P48735; -.
Other
SOURCE IDH2; Homo sapiens.
ProtoNet P48735.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; Mitochondrion; NADP; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    39  39     Mitochondrion (By similarity). 
CHAIN   40   452  413     Isocitrate dehydrogenase [NADP], mitochondrial. PRO_0000014420
NP_BIND   115   117  3     NADP (By similarity). 
NP_BIND   349   354  6     NADP (By similarity). 
REGION   134   140  7     Substrate binding (By similarity). 
METAL   291   291        Magnesium or manganese (By similarity). 
METAL   314   314        Magnesium or manganese (By similarity). 
BINDING   117   117        Substrate (By similarity). 
BINDING   122   122        NADP (By similarity). 
BINDING   149   149        Substrate (By similarity). 
BINDING   172   172        Substrate (By similarity). 
BINDING   299   299        NADP (By similarity). 
BINDING   367   367        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
SITE   179   179  1     Critical for catalysis (By similarity). 
SITE   251   251  1     Critical for catalysis (By similarity). 
MOD_RES   106   106        N6-acetyllysine (By similarity). 
MOD_RES   272   272        N6-acetyllysine (By similarity). 
CONFLICT   34    34        Q -> H (in Ref. 1; CAA49208). 
CONFLICT   435   435        T -> M (in Ref. 1; CAA49208). 
Sequence information
Length: 452 AA [This is the length of the unprocessed precursor] Molecular weight: 50909 Da [This is the MW of the unprocessed precursor] CRC64: 4DDC830AFC06AB52 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGYLRVVRS LCRASGSRPA WAPAALTAPT SQEQPRRHYA DKRIKVAKPV VEMDGDEMTR 

        70         80         90        100        110        120 
IIWQFIKEKL ILPHVDIQLK YFDLGLPNRD QTDDQVTIDS ALATQKYSVA VKCATITPDE 

       130        140        150        160        170        180 
ARVEEFKLKK MWKSPNGTIR NILGGTVFRE PIICKNIPRL VPGWTKPITI GRHAHGDQYK 

       190        200        210        220        230        240 
ATDFVADRAG TFKMVFTPKD GSGVKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYAI 

       250        260        270        280        290        300 
QKKWPLYMST KNTILKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS 

       310        320        330        340        350        360 
SGGFVWACKN YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT VTRHYREHQK 

       370        380        390        400        410        420 
GRPTSTNPIA SIFAWTRGLE HRGKLDGNQD LIRFAQMLEK VCVETVESGA MTKDLAGCIH 

       430        440        450 
GLSNVKLNEH FLNTTDFLDT IKSNLDRALG RQ
P48735 in FASTA format

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