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UniProtKB/Swiss-Prot entry P48638

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSHR_ANASP
Primary accession number P48638
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on January 23, 2002 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 63)
Name and origin of the protein
Protein name Glutathione reductase
Synonyms GRase
GR
EC 1.8.1.7
Gene name
Name: gor
OrderedLocusNames: all4968
From
Anabaena sp. (strain PCC 7120) [TaxID: 103690] [HAMAP proteome]
Taxonomy Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1074/jbc.270.39.23143; PubMed=7559423 [NCBI, ExPASy, EBI, Israel, Japan]
Jiang F., Hellman U., Sroga G.E., Bergman B., Mannervik B.;
"Cloning, sequencing, and regulation of the glutathione reductase gene from the cyanobacterium Anabaena PCC 7120.";
J. Biol. Chem. 270:22882-22889(1995).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/dnares/8.5.205; PubMed=11759840 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M., Yasuda M., Tabata S.;
"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120.";
DNA Res. 8:205-213(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X89712; CAA61856.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000019; BAB76667.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AH2426; AH2426.
I39477; I39477.
RefSeq NP_489008.1; -.
3D structure databases
HSSP Q94655; 1ONF. [HSSP ENTRY / PDB]
ModBase P48638.
Enzyme and pathway databases
BioCyc NSP103690:ALL4968-MON; -.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR006324; Glut_reduct_pln.
IPR000815; Hg_reductase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR012999; Pyr_OxRdtase_I_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00945; HGRDTASE.
PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01424; gluta_reduc_2; 1.
PROSITE PS00076; PYRIDINE_REDOX_1; 1.
BLOCKS P48638.
Genome annotation databases
GeneID 1108569; -.
GenomeReviews BA000019_GR; all4968.
KEGG ana:all4968; -.
NMPDR fig|103690.1.peg.5275; -.
Phylogenomic databases
HOGENOM P48638; -.
Genome annotation databases
CMR P48638; all4968.
Other
ProtoNet P48638.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; FAD; Flavoprotein; NADP; Oxidoreductase; Redox-active center.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   459  459     Glutathione reductase. PRO_0000067973
NP_BIND   34    42  9     FAD (By similarity). 
ACT_SITE   448   448        Proton acceptor (By similarity). 
DISULFID   42    47        Redox-active (By similarity). 
CONFLICT   234   234        E -> Q (in Ref. 1; CAA61856). 
CONFLICT   340   340        R -> L (in Ref. 1; CAA61856). 
CONFLICT   361   361        V -> L (in Ref. 1; CAA61856). 
CONFLICT   372   372        L -> H (in Ref. 1; CAA61856). 
CONFLICT   381   383        RTR -> AP (in Ref. 1; CAA61856). 
Sequence information
Length: 459 AA [This is the length of the unprocessed precursor] Molecular weight: 49478 Da [This is the MW of the unprocessed precursor] CRC64: 29C1F06CE2195888 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTFDYDLFVI GAGSGGLAAS KRAASYGAKV AIAENDLVGG TCVIRGCVPK KLMVYGSHFP 

        70         80         90        100        110        120 
ALFEDAAGYG WQVGKAELNW EHFITSIDKE VRRLSQLHIS FLEKAGVELI SGRATLVDNH 

       130        140        150        160        170        180 
TVEVGERKFT ADKILIAVGG RPIKPELPGM EYGITSNEIF HLKTQPKHIA IIGSGYIGTE 

       190        200        210        220        230        240 
FAGIMRGLGS QVTQITRGDK ILKGFDEDIR TEIQEGMTNH GIRIIPKNVV TAIEQVPEGL 

       250        260        270        280        290        300 
KISLSGEDQE PIIADVFLVA TGRVPNVDGL GLENAGVDVV DSSIEGPGYS TMNAIAVNEY 

       310        320        330        340        350        360 
SQTSQPNIYA VGDVTDRLNL TPVAIGEGRA FADSEFGNNR REFSHETIAT AVFSNPQAST 

       370        380        390        400        410        420 
VGLTEAEARA KLGDDAVTIY RTRFRPMYHS FTGKQERIMM KLVVDTKTDK VLGAHMVGEN 

       430        440        450 
AAEIIQGVAI AVKMGATKKD FDATVGIHPS SAEEFVTMR
P48638 in FASTA format

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