ID   ADH2_DROMN              Reviewed;         254 AA.
AC   P48587;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-NOV-2008, entry version 42.
DE   RecName: Full=Alcohol dehydrogenase 2;
DE            EC=1.1.1.1;
GN   Name=Adh2;
OS   Drosophila montana (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=40370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=96139062; PubMed=8583887;
RA   Nurminsky D.I., Moriyama E.N., Lozovskaya E.R., Hartl D.L.;
RT   "Molecular phylogeny and genome evolution in the Drosophila virilis
RT   species group: duplications of the alcohol dehydrogenase gene.";
RL   Mol. Biol. Evol. 13:132-149(1996).
CC   -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone +
CC       NADH.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; U26845; AAB02631.1; -; Genomic_DNA.
DR   HSSP; P10807; 1B16.
DR   SMR; P48587; 1-254.
DR   FlyBase; FBgn0013853; Dmon\Adh2.
DR   GO; GO:0004022; F:alcohol dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DHase_sc/Rdtase_SDR.
DR   InterPro; IPR002425; Insect_AlcDHase.
DR   InterPro; IPR002424; Insect_AlcDHase_fam.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR01168; ALCDHDRGNASE.
DR   PRINTS; PR01167; INSADHFAMILY.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    254       Alcohol dehydrogenase 2.
FT                                /FTId=PRO_0000054477.
FT   NP_BIND      10     33       NAD (By similarity).
FT   ACT_SITE    151    151       Proton acceptor (By similarity).
FT   BINDING     138    138       Substrate (By similarity).
SQ   SEQUENCE   254 AA;  27550 MW;  2CCC351DF26F5A56 CRC64;
     MAIANKNIIF VAGLGGIGLD TSREIVKSGP KNLVILDRID NPTAIAELKA INPKVTVTFY
     PYDVTVPVAE TTKLLKTIFA QLKTVDLLIN GAGILDDHQI ERTIAVNFTG TVNTTTAIME
     FWDKRKGGPG GVIANICSVT GFNAIYQVPV YSASKAAALS FTNSLARLAP ITGVTAYSIN
     PGITRTPLVH KFNSWLDVEP RVGELLLEHP TQTTLECAQN FVKAIEANKN GAIWQLDLGQ
     LIAVEWTKHW DSHI
//