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UniProtKB/Swiss-Prot entry P48448


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL3B2_HUMAN
Primary accession number P48448
Secondary accession numbers Q8NAL5 Q96IB2
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on June 7, 2005 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 79)
Name and origin of the protein
Protein name Aldehyde dehydrogenase family 3 member B2
Synonyms EC 1.2.1.5
Aldehyde dehydrogenase 8
Gene name
Name: ALDH3B2
Synonyms: ALDH8
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Salivary gland;
PubMed=7484374 [NCBI, ExPASy, EBI, Israel, Japan]
Hsu L.C., Chang W.-C., Lin S.W., Yoshida A.;
"Cloning and characterization of genes encoding four additional human aldehyde dehydrogenase isozymes.";
Adv. Exp. Med. Biol. 372:159-168(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Salivary gland;
DOI=10.1016/0378-1119(96)00087-X; PubMed=8890755 [NCBI, ExPASy, EBI, Israel, Japan]
Hsu L.C., Chang W.-C.;
"Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family.";
Gene 174:319-322(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U37519; AAA85441.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK092464; BAC03897.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC007685; AAH07685.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC5019; JC5019.
RefSeq NP_000686.2; -.
NP_001026786.1; -.
UniGene Hs.87539
3D structure databases
HSSP P11883; 1AD3. [HSSP ENTRY / PDB]
ModBase P48448.
Organism-specific databases
HGNC HGNC:411; ALDH3B2.
GenAtlas ALDH3B2.
MIM 601917; gene. [NCBI / EBI]
PharmGKB PA24700; -.
GeneCards P48448.
Gene expression databases
ArrayExpress P48448; -.
CleanEx HS_ALDH3B2; -.
GermOnline ENSG00000132746; Homo sapiens.
Ontologies
GO
GO:0004028; Molecular function: 3-chloroallyl aldehyde dehydrogenase activity (traceable author statement from ProtInc).
GO:0006066; Biological process: cellular alcohol metabolic process (traceable author statement from ProtInc).
GO:0006629; Biological process: lipid metabolic process (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR016163; Ald_DHase_C.
IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR012394; Ald_DHase_NAD(P).
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF15; ALDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS P48448.
Genome annotation databases
Ensembl ENSG00000132746; Homo sapiens. [Contig view]
GeneID 222; -.
KEGG hsa:222; -.
Phylogenomic databases
HOGENOM P48448; -.
HOVERGEN P48448; -.
Other
DrugBank DB00157; NADH.
SOURCE ALDH3B2; Homo sapiens.
ProtoNet P48448.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NAD; Oxidoreductase; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   385  385     Aldehyde dehydrogenase family 3 member B2. PRO_0000056484
NP_BIND   107   112  6     NAD (By similarity). 
ACT_SITE   129   129        By similarity. 
ACT_SITE   163   163        By similarity. 
VARIANT   50    50  1     A -> T (in dbSNP:rs3741178 [NCBI]). VAR_022058 
CONFLICT   2     2        K -> E (in Ref. 3; BAC03897). 
CONFLICT   47    49        ALA -> TLP (in Ref. 1 and 2). 
CONFLICT   52    52        N -> S (in Ref. 4; AAH07685). 
CONFLICT   132   132        G -> V (in Ref. 3; BAC03897). 
CONFLICT   276   276        R -> W (in Ref. 4; AAH07685). 
CONFLICT   290   290        S -> R (in Ref. 1 and 2). 
CONFLICT   361   361        R -> H (in Ref. 4; AAH07685). 
Sequence information
Length: 385 AA [This is the length of the unprocessed precursor] Molecular weight: 42670 Da [This is the MW of the unprocessed precursor] CRC64: ED91203A6194B240 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKDEPRSTNL FMKLDSVFIW KEPFGLVLII APWNYPLNLT LVLLVGALAA GNCVVLKPSE 

        70         80         90        100        110        120 
ISQGTEKVLA EVLPQYLDQS CFAVVLGGPQ ETGQLLEHKL DYIFFTGSPR VGKIVMTAAT 

       130        140        150        160        170        180 
KHLTPVTLEL GGKNPCYVDD NCDPQTVANR VAWFCYFNAG QTCVAPDYVL CSPEMQERLL 

       190        200        210        220        230        240 
PALQSTITRF YGDDPQSSPN LGRIINQKQF QRLRALLGCG RVAIGGQSNE SDRYIAPTVL 

       250        260        270        280        290        300 
VDVQETEPVM QEEIFGPILP IVNVQSVDEA IKFINRQEKP LALYAFSNSS QVVNQMLERT 

       310        320        330        340        350        360 
SSGSFGGNEG FTYISLLSVP FGGVGHSGMG RYHGKFTFDT FSHHRTCLLA PSGLEKLKEI 

       370        380 
RYPPYTDWNQ QLLRWGMGSQ SCTLL 

P48448 in FASTA format

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