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UniProtKB/Swiss-Prot entry P47740

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL3A2_MOUSE
Primary accession number P47740
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 64)
Name and origin of the protein
Protein name Fatty aldehyde dehydrogenase
Synonyms EC 1.2.1.3
Aldehyde dehydrogenase family 3 member A2
Aldehyde dehydrogenase 3
Gene name
Name: Aldh3a2
Synonyms: Ahd-3, Ahd3, Aldh3, Aldh4
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6 X CBA;
TISSUE=Liver;
PubMed=8634152 [NCBI, ExPASy, EBI, Israel, Japan]
Vasiliou V., Kozak C.A., Lindahl R., Nebert D.W.;
"Mouse microsomal class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping.";
DNA Cell Biol. 15:235-245(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U14390; AAB06232.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Mm.398221
3D structure databases
HSSP P11883; 1AD3. [HSSP ENTRY / PDB]
ModBase P47740.
Organism-specific databases
MGI MGI:1353452; Aldh3a2.
Gene expression databases
ArrayExpress P47740; -.
CleanEx MM_ALDH3A2; -.
GermOnline ENSMUSG00000010025; Mus musculus.
Ontologies
GO
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR012394; Ald_DHase_NAD(P).
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF15; ALDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036492; ALDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS P47740.
Genome annotation databases
Ensembl ENSMUSG00000010025; Mus musculus. [Contig view]
Phylogenomic databases
HOVERGEN P47740; -.
Other
SOURCE Aldh3a2; Mus musculus.
ProtoNet P47740.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Membrane; NAD; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   484  484     Fatty aldehyde dehydrogenase. PRO_0000056475
TOPO_DOM   1   463  463     Cytoplasmic. 
TRANSMEM   464   480  17     Potential. 
NP_BIND   185   190  6     NAD (Potential). 
MOTIF   481   484  4     Prevents secretion from ER (By similarity). 
ACT_SITE   207   207        By similarity. 
ACT_SITE   241   241        By similarity. 
Sequence information
Length: 484 AA [This is the length of the unprocessed precursor] Molecular weight: 53943 Da [This is the MW of the unprocessed precursor] CRC64: 098A49260D376C81 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MERQVLRLRQ AFRSGRSRLL RFRLQQLEAL RRMVQEREKE ILAAIAADLS KSELNAYSHE 

        70         80         90        100        110        120 
VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE PLGVVLIIGA WNYPFVLTMQ 

       130        140        150        160        170        180 
PLVGAIAAGN AAIVKPSELS ENTAKILAEL LPQYLDQDLY AIVNGGIPET TELLKQRFDH 

       190        200        210        220        230        240 
ILYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDRDC DLDVACRRVA WGKYMNCGQT 

       250        260        270        280        290        300 
CIAPDYILCE ASLQNQIVQK IKETVKDFYG ENIKASPDYE RIINLRHFKR LQSLLKGQKI 

       310        320        330        340        350        360 
AFGGEMDEAT RYLAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVDEAIN FINDREKPLA 

       370        380        390        400        410        420 
LYVFSRNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG GVGASGMGAY HGKYSFDAFS 

       430        440        450        460        470        480 
HQRPCLLKGL KGESVNKLRY PPNSESKVSW AKFFLLKQFN KGRLGMLLFV CLVAVAAVIV 


KDQL
P47740 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
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