NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=P6;
PubMed=8126007 [NCBI, ExPASy, EBI, Israel, Japan]
Asturias J.A., Eltis L.D., Prucha M., Timmis K.N.;
"Analysis of three 2,3-dihydroxybiphenyl 1,2-dioxygenases found in Rhodococcus globerulus P6. Identification of a new family of extradiol dioxygenases.";
J. Biol. Chem. 269:7807-7815(1994).

Comments

CATALYTIC ACTIVITY: Biphenyl-2,3-diol + O₂ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H₂O.
COFACTOR: Fe(2+) ion.
PATHWAY: Xenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4-pentadienoic acid and benzoic acid from biphenyl: step 3/4 .
SUBUNIT: Homohexamer (By similarity).
SIMILARITY: Belongs to the extradiol ring-cleavage dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X75635; CAA53299.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

D53419; D53419.

3D structure databases

HSSP

O05205; 1KMZ. [HSSP ENTRY / PDB]

ModBase

P47233.

Ontologies

GO:0018583;	Molecular function: biphenyl-2,3-diol 1,2-dioxygenase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR004360; Glyas_bleo-R_dOase.
IPR000486; Xdiol_dOase_1_2.
Graphical view of domain structure.

Pfam

PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.

ProDom

PD002334; Gly_diox; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00082; EXTRADIOL_DIOXYGENAS; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aromatic hydrocarbons catabolism; Dioxygenase; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 190`	`189`	`Biphenyl-2,3-diol 1,2-dioxygenase 3.`	`PRO_0000085039`
`METAL`	`9 9`		`Iron (By similarity).`
`METAL`	`73 73`		`Iron (By similarity).`
`METAL`	`121 121`		`Iron (By similarity).`

Sequence information

Length: 190 AA [This is the length of the unprocessed precursor]

Molecular weight: 21191 Da [This is the MW of the unprocessed precursor]

CRC64: 5CA026ED8D13C7E2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTVTPRLAHF VLQTNQLPAM TQWYIDVLGA HVVYENPAMC FLTTDEEHHR VALFGPPGGG 

        70         80         90        100        110        120 
LPERTPATVG LAHTAFTFPT LGDLIDKYLQ LRDKGIEPRV PVQHGVTTSL YYRDPDGNMV 

       130        140        150        160        170        180 
ELQIDNFATP EESTDYMHGE EYTTDTIGPS FNPLALAEAY KAGVPESELT TRAWALKTEQ 

       190 
INVMERMLTP

P47233 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools