NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=P6;
PubMed=8126007 [NCBI, ExPASy, EBI, Israel, Japan]
Asturias J.A., Eltis L.D., Prucha M., Timmis K.N.;
"Analysis of three 2,3-dihydroxybiphenyl 1,2-dioxygenases found in Rhodococcus globerulus P6. Identification of a new family of extradiol dioxygenases.";
J. Biol. Chem. 269:7807-7815(1994).

Comments

CATALYTIC ACTIVITY: Biphenyl-2,3-diol + O₂ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H₂O.
COFACTOR: Fe(2+) ion.
PATHWAY: Xenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4-pentadienoic acid and benzoic acid from biphenyl: step 3/4 .
SIMILARITY: Belongs to the extradiol ring-cleavage dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X75633; CAA53297.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

B53419; B53419.

3D structure databases

HSSP

P47228; 1KND. [HSSP ENTRY / PDB]

ModBase

P47231.

Family and domain databases

InterPro

IPR017626; DiOHbiphenyl_dOase.
IPR004360; Glyas_bleo-R_dOase.
IPR000486; Xdiol_dOase_1_2.
Graphical view of domain structure.

Pfam

PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.

ProDom

PD002334; Gly_diox; 2.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00082; EXTRADIOL_DIOXYGENAS; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aromatic hydrocarbons catabolism; Dioxygenase; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 291`	`291`	`Biphenyl-2,3-diol 1,2-dioxygenase 1.`	`PRO_0000085037`
`METAL`	`146 146`		`Iron (By similarity).`
`METAL`	`210 210`		`Iron (By similarity).`
`METAL`	`260 260`		`Iron (By similarity).`

Sequence information

Length: 291 AA [This is the length of the unprocessed precursor]

Molecular weight: 32081 Da [This is the MW of the unprocessed precursor]

CRC64: 104F189FE1EDDA6A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVQRLGYLG IEVSDVDAWR TYATMRLGAM EAPAPEGTAR FRLDSRAWRF MVTPGPADDL 

        70         80         90        100        110        120 
SVAGYEVDSE GALMQVKTRL EAYGVKVTSE SSELAAERGV LGLISCVDPA GTRLEIYYGG 

       130        140        150        160        170        180 
TEMFEVPFAS PTGVKEFRTD DQGMGHYVLA VPDVDAALDF YVQGLGFHLS DVIDWQVSPE 

       190        200        210        220        230        240 
VSVRLHFLHC NGRHHTLAVV GMPSDKKMHH LMIETTNLDD VGLAYDRCVE DDAVILTLGR 

       250        260        270        280        290 
HTNDHMVSFY GATPSGFAVE FGWGSRVVEP GWSVVRYDAI SIWGHKIMRG E

P47231 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools