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UniProtKB/Swiss-Prot entry P46725


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name P5CR_MYCLE
Primary accession number P46725
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 52)
Name and origin of the protein
Protein name Pyrroline-5-carboxylate reductase
Synonyms P5C reductase
P5CR
EC 1.5.1.2
Gene name
Name: proC
OrderedLocusNames: ML2430
ORFNames: B2168_C2_211
From
Mycobacterium leprae [TaxID: 1769] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Smith D.R., Robison K.;
Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TN;
DOI=10.1038/35059006; PubMed=11234002 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G.;
"Massive gene decay in the leprosy bacillus.";
Nature 409:1007-1011(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U00018; AAA17233.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL583925; CAC31947.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S72897; S72897.
RefSeq NP_302575.1; -.
3D structure databases
ModBase P46725.
Enzyme and pathway databases
BioCyc MLEP272631:ML2430-MON; -.
Organism-specific databases
Leproma ML2430; -.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11645; P5CR; 1.
Pfam PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000193; Pyrrol-5-carb_rd; 1.
TIGRFAMs TIGR00112; proC; 1.
PROSITE PS00521; P5CR; 1.
BLOCKS P46725.
Genome annotation databases
GeneID 908565; -.
GenomeReviews AL450380_GR; ML2430.
KEGG mle:ML2430; -.
NMPDR fig|272631.1.peg.1447; -.
Phylogenomic databases
HOGENOM P46725; -.
Genome annotation databases
CMR P46725; ML2430.
Other
ProtoNet P46725.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   294  294     Pyrroline-5-carboxylate reductase. PRO_0000187293
Sequence information
Length: 294 AA [This is the length of the unprocessed precursor] Molecular weight: 30237 Da [This is the MW of the unprocessed precursor] CRC64: EA8606C9CBBB6D9D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLSSMARIAI IGGGSIGEAL LSGLLRAGRQ VKDLVVAERM PDRARYLADT YSVLVTSVTD 

        70         80         90        100        110        120 
AVENAMFVVV AVKPTDVESV MGDLVQAAAV ANDSAEQVLV TVAAGVTITY LESKLPAGTP 

       130        140        150        160        170        180 
VVRAMPNAAA LVGAGVTVLA KGRFVTGQQF EDVLAMFDAV GGVLTVPESQ MDAVTAVSGS 

       190        200        210        220        230        240 
GPAYFFLLVE ALVDAGVAVG LTRQVATELA AQTMAGSAAM LLERMDQDRH SAEVAPLGAQ 

       250        260        270        280        290 
VDVPAAQLRA TITSPGGTTA AALRELERGG LRMVVDAAVQ AAKIRSEQLR ITSE 

P46725 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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