ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P46418


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name GSTA5_RAT
Primary accession number P46418
Secondary accession number Q6LD91
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 67)
Name and origin of the protein
Protein name Glutathione S-transferase alpha-5
Synonyms EC 2.5.1.18
Glutathione S-transferase Yc-2
GST Yc2
GST A5-5
Gene name
Name: Gsta5
Synonyms: Gstyc2
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Fischer 344;
TISSUE=Liver;
PubMed=8051171 [NCBI, ExPASy, EBI, Israel, Japan]
Hayes J.D., Nguyen T., Judah D.J., Petersson D.G., Neal G.E.;
"Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1.";
J. Biol. Chem. 269:20707-20717(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8761455 [NCBI, ExPASy, EBI, Israel, Japan]
Pulford D.J., Hayes J.D.;
"Characterization of the rat glutathione S-transferase Yc2 subunit gene, GSTA5: identification of a putative antioxidant-responsive element in the 5'-flanking region of rat GSTA5 that may mediate chemoprotection against aflatoxin B1.";
Biochem. J. 318:75-84(1996).
[3]
PARTIAL PROTEIN SEQUENCE.
STRAIN=Fischer 344;
TISSUE=Liver;
PubMed=1953636 [NCBI, ExPASy, EBI, Israel, Japan]
Hayes J.D., Judah D.J., McLellan L.I., Kerr L.A., Peacock S.D., Neal G.E.;
"Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide.";
Biochem. J. 279:385-398(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X78847; CAA55404.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S72506; AAP21065.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S82820; AAB46796.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A54858; A54858.
RefSeq NP_001009920.1; -.
UniGene Rn.120929
3D structure databases
HSSP P08263; 1K3O. [HSSP ENTRY / PDB]
SMR P46418; 4-220.
ModBase P46418.
Organism-specific databases
RGD 2753; Gsta5.
Gene expression databases
ArrayExpress P46418; -.
GermOnline ENSRNOG00000029711; Rattus norvegicus.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004364; Molecular function: glutathione transferase activity (inferred from electronic annotation from InterPro).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR010987; Glutathione-S-Trfase_C-like.
IPR003080; GST_alpha.
IPR004046; GST_C.
IPR004045; GST_N.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1050.10; GST_C_like; 1.
G3DSA:3.40.30.10; Thioredoxin_fold; 1.
PANTHER PTHR11571:SF4; GST_alpha; 1.
Pfam PF00043; GST_C; 1.
PF02798; GST_N; 1.
Pfam graphical view of domain structure.
PRINTS PR01266; GSTRNSFRASEA.
PROSITE PS50405; GST_CTER; 1.
PS50404; GST_NTER; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSRNOG00000029711; Rattus norvegicus. [Contig view]
GeneID 494500; -.
KEGG rno:494500; -.
NMPDR fig|10116.3.peg.29792; -.
Phylogenomic databases
HOVERGEN P46418; -.
Other
NextBio 697639; -.
ProtoNet P46418.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Direct protein sequencing; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   221  220     Glutathione S-transferase alpha-5. PRO_0000185796
DOMAIN   3    83  81     GST N-terminal. 
DOMAIN   85   207  123     GST C-terminal. 
Sequence information
Length: 221 AA [This is the length of the unprocessed precursor] Molecular weight: 25347 Da [This is the MW of the unprocessed precursor] CRC64: EEDE9873765BFDB5 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPGKPVLHYF DGRGRMEPIR WLLAAAGVEF EENFLKTRDD LARLRSDGSL MFEQVPMVEI 

        70         80         90        100        110        120 
DGMKLVQTKA ILNYIATKYN LYGKDMKERA LIDMYAEGVA DLELMVLYYP YMPPGEKEAS 

       130        140        150        160        170        180 
LAKIKDKARN RYFPAYEKVL KSHGQDYLVG NKLSRADVSL VELLYHVEEM DPGIVDNFPL 

       190        200        210        220 
LKALRTRVSN LPTVKKFLQP GSQRKPFDDE KCVESAKKIF S 

P46418 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!