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UniProtKB/Swiss-Prot entry P45952

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACADM_MOUSE
Primary accession number P45952
Secondary accession number Q64235
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    September 23, 2008 (Entry version 80)
Name and origin of the protein
Protein name Medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Precursor]
Synonyms MCAD
EC 1.3.99.3
Gene name
Name: Acadm
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/c;
TISSUE=Liver;
DOI=10.1006/geno.1994.1486; PubMed=7829081 [NCBI, ExPASy, EBI, Israel, Japan]
Tolwani R.J., Farmer S.C., Wood P.A.;
"Molecular cloning and characterization of the mouse medium-chain acyl-CoA dehydrogenase cDNA.";
Genomics 23:247-249(1994).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-193.
PubMed=1438358 [NCBI, ExPASy, EBI, Israel, Japan]
Wood P.A., Farmer S.C., Tolwani R.J., Warren J.R., Steinkampf M.P., Johnson L.W., Mountz J.D., Kelly D.P.;
"Molecular studies of mouse medium and long-chain acyl-CoA dehydrogenase genes for site-directed mutagenesis of embryonic stem cells.";
Prog. Clin. Biol. Res. 375:151-160(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U07159; AAA76733.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S48761; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
S48759; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
PIR A55724; A55724.
RefSeq NP_031408.1; -.
UniGene Mm.10530
3D structure databases
HSSP P11310; 1EGD. [HSSP ENTRY / PDB]
SMR P45952; 35-421.
ModBase P45952.
2D gel databases
SWISS-2DPAGE P45952; -.
Organism-specific databases
MGI MGI:87867; Acadm.
Gene expression databases
ArrayExpress P45952; -.
CleanEx MM_ACADM; -.
GermOnline ENSMUSG00000062908; Mus musculus.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from direct assay from MGI).
GO:0003995; Molecular function: acyl-CoA dehydrogenase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0055007; Biological process: cardiac muscle cell differentiation (inferred from mutant phenotype from MGI).
GO:0009437; Biological process: carnitine metabolic process (inferred from mutant phenotype from MGI).
GO:0006635; Biological process: fatty acid beta-oxidation (inferred from sequence or structural similarity from UniProtKB).
GO:0001889; Biological process: liver development (inferred from mutant phenotype from MGI).
GO:0009791; Biological process: post-embryonic development (inferred from mutant phenotype from MGI).
GO:0009409; Biological process: response to cold (inferred from mutant phenotype from MGI).
GO:0042594; Biological process: response to starvation (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR006091; Acyl-CoA_DHase/Oxase_M.
IPR006089; Acyl-CoA_DHase_CS.
IPR006092; Acyl-CoA_DHase_N.
IPR006090; Acyl-CoA_Oxase/DHase_1.
IPR013786; AcylCoA_DH/ox_N.
IPR013764; AcylCoA_oxidase/DH_1/2_C.
Graphical view of domain structure.
Gene3D G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1.
Pfam PF00441; Acyl-CoA_dh_1; 1.
PF02770; Acyl-CoA_dh_M; 1.
PF02771; Acyl-CoA_dh_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00072; ACYL_COA_DH_1; 1.
PS00073; ACYL_COA_DH_2; 1.
BLOCKS P45952.
Genome annotation databases
Ensembl ENSMUSG00000062908; Mus musculus. [Contig view]
GeneID 11364; -.
KEGG mmu:11364; -.
NMPDR fig|10090.3.peg.9178; -.
Phylogenomic databases
HOGENOM P45952; -.
HOVERGEN P45952; -.
Other
SOURCE Acadm; Mus musculus.
ProtoNet P45952.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Mitochondrion; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    25  25     Mitochondrion (By similarity). 
CHAIN   26   421  396     Medium-chain specific acyl-CoA dehydrogenase, mitochondrial. PRO_0000000504
NP_BIND   158   167  10     FAD (By similarity). 
NP_BIND   191   193  3     FAD (By similarity). 
NP_BIND   306   308  3     FAD (By similarity). 
NP_BIND   316   317  2     FAD (By similarity). 
NP_BIND   374   378  5     FAD (By similarity). 
NP_BIND   403   405  3     FAD (By similarity). 
REGION   278   281  4     Substrate binding (By similarity). 
ACT_SITE   401   401        Proton acceptor (By similarity). 
BINDING   167   167        Substrate; via carbonyl oxygen (By similarity). 
BINDING   402   402        Substrate; via amide nitrogen (By similarity). 
CONFLICT   135   135        L -> I (in Ref. 2). 
CONFLICT   184   184        V -> A (in Ref. 2). 
Sequence information
Length: 421 AA [This is the length of the unprocessed precursor] Molecular weight: 46481 Da [This is the MW of the unprocessed precursor] CRC64: 36976704E3E48CBB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAAAFRRGCR VLRSVSHFEC RTQHSKAAHK QEPGLGFSFE LTEQQKEFQA TARKFAREEI 

        70         80         90        100        110        120 
IPVAPEYDKS GEYPFPLIKR AWELGLINAH IPESCGGLGL GTFDACLITE ELAYGCTGVQ 

       130        140        150        160        170        180 
TAIEANSLGQ MPVILAGNDQ QKKKYLGRMT EQPMMCAYCV TEPSAGSDVA AIKTKAEKKG 

       190        200        210        220        230        240 
DEYVINGQKM WITNGGKANW YFLLARSNPD PKVPASKAFT GFIVEADTPG IHIGKKELNM 

       250        260        270        280        290        300 
GQRCSDTRGI AFEDVRVPKE NVLIGEGAGF KIAMGAFDRT RPTVAAGAVG LAQRALDEAT 

       310        320        330        340        350        360 
KYALDRKTFG KLLVEHQGVS FLLAEMAMKV ELARLSYQRA AWEVDSGRRN TYYASIAKAF 

       370        380        390        400        410        420 
AGDIANQLAT DAVQIFGGYG FNTEYPVEKL MRDAKIYQIY EGTAQIQRLI IAREHIEKYK 


N
P45952 in FASTA format

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