FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBUNIT: Homodimer (By similarity).

Copyright

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Cross-references

Sequence databases

EMBL

L42023; AAC22886.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A64112; A64112.

RefSeq

NP_439389.1; -.

3D structure databases

HSSP

P06958; 1L8A. [HSSP ENTRY / PDB]

ModBase

P45119.

Enzyme and pathway databases

BioCyc

HINF71421:HI_1233-MON; -.

Ontologies

GO:0004739;	Molecular function: pyruvate dehydrogenase (acetyl-transferring) activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR004660; 2-oxoA_DHase_E1.
IPR015941; Transketolase_C-like.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.920; Transketo_C_like; 1.

PIRSF

PIRSF000156; Pyruvate_dh_E1; 1.

TIGRFAMs

TIGR00759; aceE; 1.

BLOCKS

P45119.

Genome annotation databases

950116; -.

L42023_GR; HI1233.

hin:HI1233; -.

fig|71421.1.peg.1179; -.

TIGR

HI1233; -.

Phylogenomic databases

HOGENOM

P45119; -.

Other

ProtoNet

P45119.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Glycolysis; Oxidoreductase; Pyruvate; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 886`	`886`		`Pyruvate dehydrogenase E1 component.`	`PRO_0000162245`

Sequence information

Length: 886 AA [This is the length of the unprocessed precursor]

Molecular weight: 99131 Da [This is the MW of the unprocessed precursor]

CRC64: 1B936A75DD69E71D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSEILKNDVD PIETQDWLQS LDSLIREEGV ERAQYIVEQV IGQARTSGVS LPTGVTTDYV 

        70         80         90        100        110        120 
NTIPVAEQPA YPGDHAIERR IRSAVRWNAI AMVLRSQKKD LDLGGHISTF QSAATMYEVC 

       130        140        150        160        170        180 
YNHFFKAATE KNGGDLIFFQ GHAAPGMYAR AFLEGRLTEE QMDNFRQEAF TDGLSSYPHP 

       190        200        210        220        230        240 
KLMPEFWQFS TVSMGLGPVN AIYQARFLKY LDNRGLKDTK DQKVYAFLGD GEMDEIESKG 

       250        260        270        280        290        300 
ALTFAAREHL DNLIFTISCN LQRLDGPVNG NGKIVQELEG LFTGAGWEVI KVLWGSDWDK 

       310        320        330        340        350        360 
LFAKDTSGKL TQLMMEVVDG DYLTFKSKDG AYIREHFFGR YPETAALVAD MTDDEIWALR 

       370        380        390        400        410        420 
RGAHDSEKLY AAYAKAQNAT KPVVILAHQV KGYKIPEAES KNTAHQSKKM SYESLKGFRD 

       430        440        450        460        470        480 
FFELPLTDEQ VEKLEYIKFA EGTPEYEYLH GHRKALNGYV PARRTKFDVE YKVPALEEFK 

       490        500        510        520        530        540 
ALLEEQPRGI STTMAFTRAL NILLKDKNIG KTIVPMIADE ARTFGMEGLF RQVGIYNPHG 

       550        560        570        580        590        600 
QNYIPSDRDL VAYYREAKDG QVLQEGINEL GATASWLAAA NSYSVNNQPM IPFFIYYSMF 

       610        620        630        640        650        660 
GFQRVGDMMW AAGDQLARGF MVGGTSGRTT LNGEGLQHED GHSHIQAGII PNCITYDPSF 

       670        680        690        700        710        720 
AFEVAVIMQD GINRMYGEKQ EDVFYYMTTL NEVMDQPAMP AGAEEGIRKG LYKFETVEGK 

       730        740        750        760        770        780 
KGKGHVQLLG SGAIMRHVRE AAQILANDYG VTSDVFSAPS FNELAREGHD AARWNLLHPT 

       790        800        810        820        830        840 
ETQRVPYVAQ VLADLPTVAS TDYVKGYADQ IRAFVPSKHY HVLGTDGFGR SDSRANLREH 

       850        860        870        880 
FEVDARYVVV AALSQLAKEG TVSNQVVADA IAKFGLNVDR INPLYA

P45119 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools