ID   FRDB_HAEIN              Reviewed;         256 AA.
AC   P44893;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-NOV-2008, entry version 65.
DE   RecName: Full=Fumarate reductase iron-sulfur subunit;
DE            EC=1.3.99.1;
GN   Name=frdB; OrderedLocusNames=HI0834;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   MEDLINE=95350630; PubMed=7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA   Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA   Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA   Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA   Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA   Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- CATALYTIC ACTIVITY: Succinate + acceptor = fumarate + reduced
CC       acceptor.
CC   -!- COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
CC   -!- COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
CC   -!- SUBUNIT: Fumarate dehydrogenase forms part of an enzyme complex
CC       containing four subunits: a flavoprotein, an iron-sulfur, and two
CC       hydrophobic anchor proteins (By similarity).
CC   -!- SIMILARITY: Belongs to the succinate dehydrogenase/fumarate
CC       reductase iron-sulfur protein family.
CC   -!- SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
CC   -!- SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.
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DR   EMBL; L42023; AAC22492.1; -; Genomic_DNA.
DR   RefSeq; NP_438994.1; -.
DR   HSSP; P00364; 1KF6.
DR   SMR; P44893; 7-255.
DR   GeneID; 949848; -.
DR   GenomeReviews; L42023_GR; HI0834.
DR   KEGG; hin:HI0834; -.
DR   TIGR; HI0834; -.
DR   HOGENOM; P44893; -.
DR   BioCyc; HINF71421:HI_0834-MON; -.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000104; F:succinate dehydrogenase activity; IEA:EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR006058; 2Fe2S_fd_BS.
DR   InterPro; IPR001450; 4Fe4S_Fe_S_bd.
DR   InterPro; IPR012675; b-grasp_ferredoxin-like.
DR   InterPro; IPR001041; Ferredoxin.
DR   InterPro; IPR012285; Fum_reductase_C.
DR   InterPro; IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
DR   Gene3D; G3DSA:3.10.20.30; Ferredoxin_fold; 1.
DR   Gene3D; G3DSA:1.10.1060.10; Fum_reductase_C; 1.
DR   Pfam; PF00111; Fer2; 1.
DR   Pfam; PF00037; Fer4; 1.
DR   PRINTS; PR00353; 4FE4SFRDOXIN.
DR   TIGRFAMs; TIGR00384; dhsB; 1.
DR   PROSITE; PS00197; 2FE2S_FER_1; 1.
DR   PROSITE; PS51085; 2FE2S_FER_2; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
PE   3: Inferred from homology;
KW   2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron;
KW   Iron-sulfur; Metal-binding; Oxidoreductase; Transport;
KW   Tricarboxylic acid cycle.
FT   CHAIN         1    256       Fumarate reductase iron-sulfur subunit.
FT                                /FTId=PRO_0000158702.
FT   DOMAIN        7     97       2Fe-2S ferredoxin-type.
FT   DOMAIN      151    180       4Fe-4S ferredoxin-type.
FT   METAL        58     58       Iron-sulfur 1 (2Fe-2S) (By similarity).
FT   METAL        63     63       Iron-sulfur 1 (2Fe-2S) (By similarity).
FT   METAL        66     66       Iron-sulfur 1 (2Fe-2S) (By similarity).
FT   METAL        78     78       Iron-sulfur 1 (2Fe-2S) (By similarity).
FT   METAL       160    160       Iron-sulfur 2 (4Fe-4S) (By similarity).
FT   METAL       163    163       Iron-sulfur 2 (4Fe-4S) (By similarity).
FT   METAL       166    166       Iron-sulfur 2 (4Fe-4S) (By similarity).
FT   METAL       170    170       Iron-sulfur 3 (3Fe-4S) (By similarity).
FT   METAL       216    216       Iron-sulfur 3 (3Fe-4S) (By similarity).
FT   METAL       222    222       Iron-sulfur 3 (3Fe-4S) (By similarity).
FT   METAL       226    226       Iron-sulfur 2 (4Fe-4S) (By similarity).
SQ   SEQUENCE   256 AA;  28668 MW;  42E3851D0B6B355E CRC64;
     MANSPVMNVE VLRYNPEIDQ EPHLSTYQVP YDNQTSLLDA LGYIKDKLEP SLSYRWSCRM
     AICGSCGMMV NNKPKLACKT FLRDYSGHMR IEPLANFPIE RDLVVDLSHF IESLEAIKPY
     IIGNEAPALD GKPHPSKELQ VSRTKQTPAQ LEKYRQFSMC INCGLCYAAC PQFGLNPEFL
     GPAAITMAHR YNLDNRDHGK AKRMSLLNGK NGVWSCTFVG YCSEVCPKHV DPASAINQGK
     VESAKDYVIS MLKPKG
//