NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=8188593 [NCBI, ExPASy, EBI, Israel, Japan]
Bishai W.R., Smith H.O., Barcak G.J.;
"A peroxide/ascorbate-inducible catalase from Haemophilus influenzae is homologous to the Escherichia coli katE gene product.";
J. Bacteriol. 176:2914-2921(1994).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).

Comments

FUNCTION: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
COFACTOR: Heme group.
SUBUNIT: Homohexamer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
INDUCTION: By hydrogen peroxide.
SIMILARITY: Belongs to the catalase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U02682; AAA20441.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
L42023; AAC22587.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

D64103; D64103.

RefSeq

NP_439088.1; -.

3D structure databases

HSSP

P42321; 1M85. [HSSP ENTRY / PDB]

ModBase

P44390.

Enzyme and pathway databases

BioCyc

HINF71421:HI_0928-MON; -.

Family and domain databases

InterPro

IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.180.10; Catalase_N; 1.

PANTHER

PTHR11465; Catalase; 1.

Pfam

PF00199; Catalase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00067; CATALASE.

ProDom

PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.

BLOCKS

P44390.

Genome annotation databases

949926; -.

L42023_GR; HI0928.

hin:HI0928; -.

fig|71421.1.peg.894; -.

TIGR

HI0928; -.

Phylogenomic databases

HOGENOM

P44390; -.

Other

ProtoNet

P44390.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 508`	`508`	`Catalase.`	`PRO_0000084986`
`ACT_SITE`	`63 63`		`By similarity.`
`ACT_SITE`	`136 136`		`By similarity.`
`METAL`	`346 346`		`Iron (heme axial ligand) (By similarity).`
`CONFLICT`	`357 357`		`N -> C (in Ref. 1; AAA20441).`
`CONFLICT`	`384 384`		`N -> T (in Ref. 1; AAA20441).`
`CONFLICT`	`413 413`		`N -> S (in Ref. 1; AAA20441).`
`CONFLICT`	`423 423`		`N -> T (in Ref. 1; AAA20441).`

Sequence information

Length: 508 AA [This is the length of the unprocessed precursor]

Molecular weight: 57680 Da [This is the MW of the unprocessed precursor]

CRC64: 4FAFC16DB44043B0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSSQCPFSHL AATNLTMGNG APVADNQNSL TAGPRGPLLA QDLWLNEKLA DFVREVIPER 

        70         80         90        100        110        120 
RMHAKGSGAF GTFTVTHDIT KYTRAKIFSE VGKKTEMFAR FTTVAGERGA ADAERDIRGF 

       130        140        150        160        170        180 
ALKFYTEEGN WDLVGNNTPV FFLRDPRKFP DLNKAVKRDP RTNMRSATNN WDFWTLLPEA 

       190        200        210        220        230        240 
LHQVTVVMSD RGIPASYRHM HGFGSHTYSF WNEAGERFWV KFHFRTQQGI KNLTDAEAAE 

       250        260        270        280        290        300 
IIANDRESHQ RDLYEAIERG DFPKWTLFVQ IMPEADAEKV PYHPFDLTKV WSKKDYPLIE 

       310        320        330        340        350        360 
VGEFELNRNP ENFFADVEQS AFAPSNLVPG IGASPDRMLQ ARLFNYADAQ RYRLGVNYRQ 

       370        380        390        400        410        420 
IPVNRPRCPV HSNQRDGQGR VDGNYGSLPH YEPNSFSQWQ QQPDFAEPPL RINGDAAHWD 

       430        440        450        460        470        480 
YRNDDNDYFS QPRALFNLMN AEQKQSLFNN TAAAMGDAPD FIKYRHIRNC HWCDAAYGEG 

       490        500 
VAKALGLTVE DALKARDTDP ALGQGGLL

P44390 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools