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UniProtKB/Swiss-Prot entry P43353

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL3B1_HUMAN
Primary accession number P43353
Secondary accession numbers Q53XL5 Q8N515 Q96CK8
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 75)
Name and origin of the protein
Protein name Aldehyde dehydrogenase family 3 member B1
Synonyms EC 1.2.1.5
Aldehyde dehydrogenase 7
Gene name
Name: ALDH3B1
Synonyms: ALDH7
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Kidney;
DOI=10.1016/0378-1119(94)90672-6; PubMed=7828891 [NCBI, ExPASy, EBI, Israel, Japan]
Hsu L.C., Chang W.-C., Yoshida A.;
"Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family.";
Gene 151:285-289(1994).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Lung, and Prostate;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
 PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U10868; AAA83428.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT009832; AAP88834.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC013584; AAH13584.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014168; AAH14168.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033099; AAH33099.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I38669; I38669.
RefSeq NP_000685.1; -.
NP_001025181.1; -.
UniGene Hs.523841
3D structure databases
HSSP P11883; 1AD3. [HSSP ENTRY / PDB]
ModBase P43353.
PTM databases
PhosphoSite P43353; -.
Organism-specific databases
HGNC HGNC:410; ALDH3B1.
GenAtlas ALDH3B1.
MIM 600466; gene. [NCBI / EBI]
PharmGKB PA24699; -.
GeneCards P43353.
Gene expression databases
ArrayExpress P43353; -.
CleanEx HS_ALDH3B1; -.
GermOnline ENSG00000006534; Homo sapiens.
Ontologies
GO
GO:0004028; Molecular function: 3-chloroallyl aldehyde dehydrogenase activity (traceable author statement from ProtInc).
GO:0006066; Biological process: cellular alcohol metabolic process (traceable author statement from ProtInc).
GO:0006629; Biological process: lipid metabolic process (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR012394; Ald_DHase_NAD(P).
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF15; ALDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036492; ALDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS P43353.
Genome annotation databases
Ensembl ENSG00000006534; Homo sapiens. [Contig view]
GeneID 221; -.
KEGG hsa:221; -.
Phylogenomic databases
HOGENOM P43353; -.
HOVERGEN P43353; -.
Other
DrugBank DB00157; NADH.
SOURCE ALDH3B1; Homo sapiens.
ProtoNet P43353.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   468  468     Aldehyde dehydrogenase family 3 member B1. PRO_0000056481
NP_BIND   188   193  6     NAD (By similarity). 
ACT_SITE   210   210        By similarity. 
ACT_SITE   244   244        By similarity. 
MOD_RES   368   368        Phosphoserine. 
VAR_SEQ   55    91        Missing (in isoform 2). VSP_014040
Sequence information
Length: 468 AA [This is the length of the unprocessed precursor] Molecular weight: 51840 Da [This is the MW of the unprocessed precursor] CRC64: 30BEEB982395D2F7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ DLHKSAFESE 

        70         80         90        100        110        120 
VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI RKEPFGLVLI IAPWNYPLNL 

       130        140        150        160        170        180 
TLVPLVGALA AGNCVVLKPS EISKNVEKIL AEVLPQYVDQ SCFAVVLGGP QETGQLLEHR 

       190        200        210        220        230        240 
FDYIFFTGSP RVGKIVMTAA AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA 

       250        260        270        280        290        300 
GQTCVAPDYV LCSPEMQERL LPALQSTITR FYGDDPQSSP NLGRIINQKQ FQRLRALLGC 

       310        320        330        340        350        360 
GRVAIGGQSD ESDRYIAPTV LVDVQEMEPV MQEEIFGPIL PIVNVQSLDE AIEFINRREK 

       370        380        390        400        410        420 
PLALYAFSNS SQVVKRVLTQ TSSGGFCGND GFMHMTLASL PFGGVGASGM GRYHGKFSFD 

       430        440        450        460 
TFSHHRACLL RSPGMEKLNA LRYPPQSPRR LRMLLVAMEA QGCSCTLL
P43353 in FASTA format

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