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UniProtKB/Swiss-Prot entry P42744


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ULA1_ARATH
Primary accession number P42744
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name NEDD8-activating enzyme E1 regulatory subunit
Synonym Auxin-resistance protein AXR1
Gene name
Name: AXR1
OrderedLocusNames: At1g05180
ORFNames: YUP8H12.21
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND MUTANT AXR1-3.
STRAIN=cv. Columbia;
DOI=10.1038/364161a0; PubMed=8321287 [NCBI, ExPASy, EBI, Israel, Japan]
Leyser H.M.O., Lincoln C.A., Timpte C., Lammer D., Turner J., Estelle M.;
"Arabidopsis auxin-resistance gene AXR1 encodes a protein related to ubiquitin-activating enzyme E1.";
Nature 364:161-164(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/35048500; PubMed=11130712 [NCBI, ExPASy, EBI, Israel, Japan]
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
Nature 408:816-820(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[4]
SUBCELLULAR LOCATION, AND INTERACTION WITH ECR1 AND RUB1.
DOI=10.1126/science.280.5370.1760; PubMed=9624055 [NCBI, ExPASy, EBI, Israel, Japan]
del Pozo J.C., Timpte C., Tan S., Callis J., Estelle M.;
"The ubiquitin-related protein RUB1 and auxin response in Arabidopsis.";
Science 280:1760-1763(1998).
[5]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
DOI=10.1105/tpc.010282; PubMed=11884684 [NCBI, ExPASy, EBI, Israel, Japan]
del Pozo J.C., Dharmasiri S., Hellmann H., Walker L., Gray W.M., Estelle M.;
"AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response.";
Plant Cell 14:421-433(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L13922; AAB59348.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC000098; AAB71460.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY050379; AAK91397.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S35071; S35071.
RefSeq NP_172010.1; -.
UniGene At.10217
3D structure databases
ModBase P42744.
Protein-protein interaction databases
IntAct P42744; -.
Organism-specific databases
TAIR At1g05180; -.
Gene expression databases
ArrayExpress P42744; -.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003824; Molecular function: catalytic activity (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0009734; Biological process: auxin mediated signaling pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0006511; Biological process: ubiquitin-dependent protein catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR000594; ThiF_NAD_FAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00899; ThiF; 1.
Pfam graphical view of domain structure.
ProtoNet P42744.
Genome annotation databases
GeneID 839286; -.
GenomeReviews CT485782_GR; AT1G05180.
NMPDR fig|3702.1.peg.672; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Auxin signaling pathway; Complete proteome; Nucleotide-binding; Nucleus; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   540  540     NEDD8-activating enzyme E1 regulatory subunit. PRO_0000194960
NP_BIND   51    75  25     ATP (By similarity). 
ACT_SITE   154   154        Glycyl thioester intermediate (Probable). 
MUTAGEN   154   154        C->Y: In axr1-3; auxin-resistant. 
Sequence information
Length: 540 AA [This is the length of the unprocessed precursor] Molecular weight: 60035 Da [This is the MW of the unprocessed precursor] CRC64: 9CD0091114654B06 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQAVKRSRRH VEEEPTMVEP KTKYDRQLRI WGEVGQAALE EASICLLNCG PTGSEALKNL 

        70         80         90        100        110        120 
VLGGVGSITV VDGSKVQFGD LGNNFMVDAK SVGQSKAKSV CAFLQELNDS VNAKFIEENP 

       130        140        150        160        170        180 
DTLITTNPSF FSQFTLVIAT QLVEDSMLKL DRICRDANVK LVLVRSYGLA GFVRISVKEH 

       190        200        210        220        230        240 
PIIDSKPDHF LDDLRLNNPW PELKSFVETI DLNVSEPAAA HKHIPYVVIL VKMAEEWAQS 

       250        260        270        280        290        300 
HSGNLPSTRE EKKEFKDLVK SKMVSTDEDN YKEAIEAAFK VFAPRGISSE VQKLINDSCA 

       310        320        330        340        350        360 
EVNSNSSAFW VMVAALKEFV LNEGGGEAPL EGSIPDMTSS TEHYINLQKI YLAKAEADFL 

       370        380        390        400        410        420 
VIEERVKNIL KKIGRDPSSI PKPTIKSFCK NARKLKLCRY RMVEDEFRNP SVTEIQKYLA 

       430        440        450        460        470        480 
DEDYSGAMGF YILLRAADRF AANYNKFPGQ FDGGMDEDIS RLKTTALSLL TDLGCNGSVL 

       490        500        510        520        530        540 
PDDLIHEMCR FGASEIHVVS AFVGGIASQE VIKLVTKQFV PMLGTYIFNG IDHKSQLLKL 

P42744 in FASTA format

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