[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=08-0203-Berlin; DOI=10.1016/0161-5890(94)00108-D; PubMed=7898496 [NCBI, ExPASy, EBI, Israel, Japan] Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A., Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M.; "Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum."; Mol. Immunol. 32:213-227(1995).
[2]	SEQUENCE REVISION TO 73; 153-166; 334-336 AND 424. Simon-Nobbe B.; Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[3]	REVIEW. DOI=10.1159/000107578; PubMed=17709917 [NCBI, ExPASy, EBI, Israel, Japan] Simon-Nobbe B., Denk U., Poell V., Rid R., Breitenbach M.; "The spectrum of fungal allergy."; Int. Arch. Allergy Immunol. 145:58-86(2008).

Comments

CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2 .
SUBCELLULAR LOCATION: Cytoplasm (Probable).
ALLERGEN: Causes an allergic reaction in human.
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X78227; CAA55071.2; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S43108; S43108.

3D structure databases

HSSP

P05091; 1O04. [HSSP ENTRY / PDB]

ModBase

P42041.

Ontologies

GO:0004029;	Molecular function: aldehyde dehydrogenase (NAD) activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Allergen; Cytoplasm; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 497`	`497`	`Aldehyde dehydrogenase.`	`PRO_0000056434`
`NP_BIND`	`241 246`	`6`	`NAD (By similarity).`
`ACT_SITE`	`264 264`		`Proton acceptor (By similarity).`
`ACT_SITE`	`298 298`		`Nucleophile (By similarity).`
`SITE`	`148 148`	`1`	`Transition state stabilizer (By similarity).`

Sequence information

Length: 497 AA [This is the length of the unprocessed precursor]

Molecular weight: 53916 Da [This is the MW of the unprocessed precursor]

CRC64: 75DB63C621DFFB5C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTSVKLSTPQ TGEFEQPTGL FINNEFVKAV DGKTFDVINP STEEVICSVQ EATEKDVDIA 

        70         80         90        100        110        120 
VAAARKAFNG PWRKETPENR GKLLNKLADL FEKNADLIAA VEALDNGKAF SMAKNVDVPA 

       130        140        150        160        170        180 
AAGCLRYYGG WADKIEGKVV DTAPDSFNYI RKEPIGVCGQ IIPWNFPILM WSWKIGPAIA 

       190        200        210        220        230        240 
TGNTVVLKTA EQTPLSAYIA CKLIQEAGFP PGVINVITGF GKIAGAAMSA HMDIDKIAFT 

       250        260        270        280        290        300 
GSTVVGRQIM KSAAGSNLKK VTLELGGKSP NIVFADADLD EAIHWVNFGI YFNHGQACCA 

       310        320        330        340        350        360 
GSRIYVQEEI YDKFIQRFKE RAAQNAVGDP FAADTFQGPQ VSQLQFDRIM GYIEEGKKSG 

       370        380        390        400        410        420 
ATIETGGNRK GDKGYFIEPT IFSNVTEDMK IQQEEIFGPV CTISKFKTKA DVIKIGNNTT 

       430        440        450        460        470        480 
YGLAAAVHTS NLTTAIEVAN ALRAGTVWVN SYNTLHWQLP FGGYKESGIG RELGEAALDN 

       490 
YIQTKTVSIR LGDVLFG

P42041 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools