[1]	NUCLEOTIDE SEQUENCE. PubMed=8138153 [NCBI, ExPASy, EBI, Israel, Japan] Begun D.J.; "Evolutionary inferences from DNA variation at the 6-phosphogluconate dehydrogenase locus in natural populations of Drosophila: selection and geographic differentiation."; Genetics 136:155-171(1994).

Comments

CATALYTIC ACTIVITY: 6-phospho-D-gluconate + NADP⁺ = D-ribulose 5-phosphate + CO₂ + NADPH.
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3 .
SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U02288; AAA18587.1; -; Unassigned_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P00349; 2PGD. [HSSP ENTRY / PDB]

SMR

P41573; 3-472.

ModBase

P41573.

Organism-specific databases

FlyBase

FBgn0012849; Dsim\Pgd.

Family and domain databases

InterPro

IPR006183; 6-phosphogluconate_DHase.
IPR006114; 6PGDH_C.
IPR006113; 6PGDH_decarbox.
IPR006115; 6PGDH_NAD-bd.
IPR006184; 6PGdom_BS.
IPR013328; DHase_multihelical.
IPR012284; Fibritin/6PGD_C-extension.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.5.320; Fibritin/6PGD_C-extension; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.

Pfam

PF00393; 6PGD; 1.
PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.

PRINTS

PR00076; 6PGDHDRGNASE.

TIGR00873; gnd; 1.

PS00461; 6PGD; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Gluconate utilization; NADP; Oxidoreductase; Pentose shunt.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 481`	`481`		`6-phosphogluconate dehydrogenase, decarboxylating.`	`PRO_0000090070`

Sequence information

Length: 481 AA [This is the length of the unprocessed precursor]

Molecular weight: 52394 Da [This is the MW of the unprocessed precursor]

CRC64: 49F97625D5B94822 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSGQADIALI GLAVMGQNLI LNMDEKGFVV CAYNRTVAKV KEFLANEAKG TNVIGADSLK 

        70         80         90        100        110        120 
DMVSKLKSPR KVMLLVKGGS AVDDFIQQLV PLLSAGDVII DGGNSEYQDT SRRCDELAKL 

       130        140        150        160        170        180 
GLLYVGSGVS GGEEGARHGP SLMPGGHEAA WPLIQPIFQA ICAKADGEPC CEWVGDGGAG 

       190        200        210        220        230        240 
HFVKMVHNGI EYGDMQLICE AYHIMQSLGL SADQMADEFG KWNSAELDSF LIEITRDILK 

       250        260        270        280        290        300 
YKDGKGHLLE RIRDTAGQKG TGKWTAIAAL QYGVPVTLIG EAVFSRCLSA LKDERVQASS 

       310        320        330        340        350        360 
VLKGPSTKAE VANLTKFLDD IKHALYCAKI VSYAQGFMLM REAARENKWR LNYGGIALMW 

       370        380        390        400        410        420 
RGGCIIRSVF LGNIKDAYTS QPQLSNLLLD DFFKKAIERG QDSWREVVAN AFRWGIPVPA 

       430        440        450        460        470        480 
LSTALSFYDG YRTAKLPANL LQAQRDYFGA HTYELLGQEG QFHHTNWTGT GGNVSASTYQ 


A

P41573 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools