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UniProtKB/Swiss-Prot entry P41563

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH3A_BOVIN
Primary accession number P41563
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [Precursor]
Synonyms EC 1.1.1.41
Isocitric dehydrogenase
NAD(+)-specific ICDH
Isocitrate dehydrogenase subunits 3/4
Gene name
Name: IDH3A
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
PubMed=7654189 [NCBI, ExPASy, EBI, Israel, Japan]
Zeng Y., Weiss C., Yao T.T., Huang J., Siconolfi-Baez L., Hsu P., Rushbrook J.I.;
"Isocitrate dehydrogenase from bovine heart: primary structure of subunit 3/4.";
Biochem. J. 310:507-516(1995).
[2]
 CHARACTERIZATION.
TISSUE=Heart;
DOI=10.1021/bi00618a003; PubMed=215197 [NCBI, ExPASy, EBI, Israel, Japan]
Rushbrook J.I., Harvey R.A.;
"Nicotinamide adenine dinucleotide dependent isocitrate dehydrogenase from beef heart: subunit heterogeneity and enzyme dissociation.";
Biochemistry 17:5339-5346(1978).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U07980; AAC18425.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S58435; S58435.
RefSeq NP_777069.1; -.
UniGene Bt.3898
3D structure databases
HSSP P08200; 1ISO. [HSSP ENTRY / PDB]
ModBase P41563.
Protein-protein interaction databases
IntAct P41563; -.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from sequence or structural similarity from AgBase).
QuickGo view.
Family and domain databases
InterPro IPR004434; IsoCit_DHase_NAD_mit.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00175; mito_nad_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS P41563.
Genome annotation databases
Ensembl ENSBTAG00000006227; Bos taurus. [Contig view]
GeneID 282446; -.
KEGG bta:282446; -.
Phylogenomic databases
HOVERGEN P41563; -.
Other
ProtoNet P41563.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    27  27     Mitochondrion. 
CHAIN   28   366  339     Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial. PRO_0000014435
METAL   233   233        Magnesium or manganese (By similarity). 
METAL   257   257        Magnesium or manganese (By similarity). 
METAL   261   261        Magnesium or manganese (By similarity). 
BINDING   115   115        Substrate (By similarity). 
BINDING   125   125        Substrate (By similarity). 
BINDING   146   146        Substrate (By similarity). 
BINDING   233   233        Substrate (By similarity). 
SITE   153   153  1     Critical for catalysis (By similarity). 
SITE   200   200  1     Critical for catalysis (By similarity). 
Sequence information
Length: 366 AA [This is the length of the unprocessed precursor] Molecular weight: 39668 Da [This is the MW of the unprocessed precursor] CRC64: B169D59B30E51C9F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGPAWISKV SRLLGAFHNQ KQVTRGFAGG VKTVTLIPGD GIGPEISAAV MKIFDAAKAP 

        70         80         90        100        110        120 
IQWEERNVAA IQGPGGKWMI PPEAKESMDK NKMGLKGPLK TPIAAGHPSM NLLLRKTFDL 

       130        140        150        160        170        180 
YANVRPCVSI EGYKTPYHDV NIVTIRENTE GEYSGIEHVI VDGVVQSIKL ITEAASKRIA 

       190        200        210        220        230        240 
EFAFEYARNN HRSNVTAVHK ANIMRMSDGL FLQKCREVAE NCKDIKFNEM YLDTVCLNMV 

       250        260        270        280        290        300 
QDPSQFDVLV MPNLYGDILS DLCAGLIGGL GVTPSGNIGA NGVAIFESVH GTAPDIAGKD 

       310        320        330        340        350        360 
MANPTALLLS AVMMLRHMGL FDHAAKIETA CFATIKDGKS LTKDLGGNSK CSDFTEEICR 


RVKDLD
P41563 in FASTA format

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