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UniProtKB/Swiss-Prot entry P41560

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH1_COLMA
Primary accession number P41560
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 56)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP] 1
Synonyms EC 1.1.1.42
IDH-I
Oxalosuccinate decarboxylase 1
NADP(+)-specific ICDH 1
IDP-1
Gene name
Name: icdI
From
Colwellia maris (Vibrio sp. (strain ABE-1)) [TaxID: 77524] 
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales; Colwelliaceae; Colwellia.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8226630 [NCBI, ExPASy, EBI, Israel, Japan]
Ishii A., Suzuki M., Sahara T., Takada Y., Sasaki S., Fukunaga N.;
"Genes encoding two isocitrate dehydrogenase isozymes of a psychrophilic bacterium, Vibrio sp. strain ABE-1.";
J. Bacteriol. 175:6873-6880(1993).
[2]
 PROTEIN SEQUENCE OF 2-41.
PubMed=1295895 [NCBI, ExPASy, EBI, Israel, Japan]
Fukunaga N., Imagawa S., Sahara T., Ishii A., Suzuki M.;
"Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4.";
J. Biochem. 112:849-855(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D14047; BAA03135.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B49341; B49341.
3D structure databases
HSSP P08200; 1PB1. [HSSP ENTRY / PDB]
SMR P41560; 1-415.
ModBase P41560.
Family and domain databases
InterPro IPR004439; IsoCit_DHase_NADP_prok.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF1; NADP_IDH_prok; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00183; prok_nadp_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS P41560.
Other
ProtoNet P41560.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   415  414     Isocitrate dehydrogenase [NADP] 1. PRO_0000083550
NP_BIND   339   345  7     NADP (By similarity). 
METAL   307   307        Magnesium or manganese (By similarity). 
BINDING   104   104        NADP (By similarity). 
BINDING   113   113        Substrate (By similarity). 
BINDING   115   115        Substrate (By similarity). 
BINDING   119   119        Substrate (By similarity). 
BINDING   129   129        Substrate (By similarity). 
BINDING   153   153        Substrate (By similarity). 
BINDING   352   352        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   390   390        NADP (By similarity). 
BINDING   394   394        NADP (By similarity). 
SITE   160   160  1     Critical for catalysis (By similarity). 
SITE   230   230  1     Critical for catalysis (By similarity). 
MOD_RES   113   113        Phosphoserine (By similarity). 
CONFLICT   26    26        N -> G (in Ref. 2; AA sequence). 
Sequence information
Length: 415 AA [This is the length of the unprocessed precursor] Molecular weight: 45145 Da [This is the MW of the unprocessed precursor] CRC64: 353EFF202824696E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTNKIIIPTT GDKITFIDGK LSVPNNPIIP YIEGDGIGVD VTPPMLKVVN AAVAKAYGGD 

        70         80         90        100        110        120 
RKIEWLEVYA GEKATKMYDS ETWLPEETLN ILQEYKVSIK GPLTTPVGGG MSSLNVAIRQ 

       130        140        150        160        170        180 
MLDLYVCQRP VQWFTGVPSP VKRPSEVDMV IFRENTEDIY AGIEYKAGSD KAKSVIKFLI 

       190        200        210        220        230        240 
EEMGASNIRF TENCGIGIKP VSKEGSQRLV RQAIQYAIDN NKDSVTLVHK GNIMKFTEGA 

       250        260        270        280        290        300 
FKDWGYELAI EEFGASLLHG GPWCSLKNPN TGKEIIIKDV IADAMLQQVL LRPAEYSVIA 

       310        320        330        340        350        360 
TLNLNGDYLS DALAAQVGGI GIAPGANLGD EVAVFEATHG TAPKYAGKNK VNPGSVILSA 

       370        380        390        400        410 
EMMLRHMGWL EADLLLKGMS GAIQAKTVTY DFERLMDDAT LVSCSAFGDC IIDHM
P41560 in FASTA format

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