NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGENICITY.
STRAIN=280202-Berlin;
DOI=10.1016/0161-5890(94)00108-D; PubMed=7898496 [NCBI, ExPASy, EBI, Israel, Japan]
Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A., Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M.;
"Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum.";
Mol. Immunol. 32:213-227(1995).

[2]

SEQUENCE REVISION TO 66; 74; 95; 110; 114-121; 158-165 AND 367.
Simon-Nobbe B.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
SUBCELLULAR LOCATION: Cytoplasm (Probable).
ALLERGEN: Causes an allergic reaction in human.
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X78228; CAA55072.2; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S43114; S43114.

3D structure databases

HSSP

P05091; 1O04. [HSSP ENTRY / PDB]

ModBase

P40108.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Allergen; Cytoplasm; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 496`	`496`	`Aldehyde dehydrogenase.`	`PRO_0000056437`
`ACT_SITE`	`263 263`		`By similarity.`
`ACT_SITE`	`296 296`		`By similarity.`

Sequence information

Length: 496 AA [This is the length of the unprocessed precursor]

Molecular weight: 53554 Da [This is the MW of the unprocessed precursor]

CRC64: D938B5D0D9B26999 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTSVQLETPH SGKYEQPTGL FINNEFVKGQ EGKTFDVINP SDESVITQVH EATEKDVDIA 

        70         80         90        100        110        120 
VAAARKAFEG SWRQETPENR GKLLNNLANL FEKNIDLLAA VESLDNGKAI SMAKGDISMC 

       130        140        150        160        170        180 
VGCLRYYGGW ADKITGKVID TTPDTFNYVK KEPIGVCGQI IPWNFPLLMW AWKIGPAIAC 

       190        200        210        220        230        240 
GNTVVLKTAE QTPLGGLVAA SLVKEAGFPP GVINVISGFG KVAGAALSSH MDVDKVAFTG 

       250        260        270        280        290        300 
STVVGRTILK AAASSNLKKV TLELGGKSPN IVFEDADIDN AISWVNFGIF FNHGQCCCAG 

       310        320        330        340        350        360 
SRVYVQESIY DKFVQKFKER AQKNVVGDPF AADTFQGPQV SKVQFDRIME YIQAGKDAGA 

       370        380        390        400        410        420 
TVETGGKRKG DKGYFIEPTI FSNVTEDMKI VKEEIFGPVC SIAKFKTKED AIKLGNASTY 

       430        440        450        460        470        480 
GLAAAVHTKN LNTAIEVSNA LKAGTVWVNT YNTLHHQMPF GGYKESGIGR ELGEDALANY 

       490 
TQTKTVSIRL GDALFG

P40108 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools