NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-24.
PubMed=8550525 [NCBI, ExPASy, EBI, Israel, Japan]
Soehling B., Gottschalk G.;
"Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri.";
J. Bacteriol. 178:871-880(1996).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0711093105; PubMed=18218779 [NCBI, ExPASy, EBI, Israel, Japan]
Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G.;
"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features.";
Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008).

Comments

CATALYTIC ACTIVITY: Succinate semialdehyde + NAD(P)⁺ + H₂O = succinate + NAD(P)H.
SIMILARITY: To the N-terminal of C.acetobutylicum or E.coli multifunctional alcohol dehydrogenase (adhE).

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L21902; AAA92347.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000673; EDK35023.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001396394.1; -.

3D structure databases

ModBase

P38947.

Enzyme and pathway databases

BioCyc

MetaCyc:MON-13462; -.

Family and domain databases

InterPro

IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

BLOCKS

P38947.

Genome annotation databases

GeneID

5394466; -.

GenomeReviews

CP000673_GR; CKL_3015.

KEGG

ckl:CKL_3015; -.

CMR

P38947; CKL_3015.

Other

ProtoNet

P38947.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Direct protein sequencing; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 453`	`453`	`Succinate-semialdehyde dehydrogenase [NAD(P)+].`	`PRO_0000072297`
`NP_BIND`	`188 193`	`6`	`NADP (By similarity).`
`ACT_SITE`	`242 242`		`By similarity.`
`CONFLICT`	`16 16`		`V -> A (in Ref. 1; AAA92347).`
`CONFLICT`	`379 379`		`A -> ARTVLPISRLVVNQPATTAG (in Ref. 1; AAA92347).`

Sequence information

Length: 453 AA [This is the length of the unprocessed precursor]

Molecular weight: 48968 Da [This is the MW of the unprocessed precursor]

CRC64: 61706F0AEBC865D7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSNEVSIKEL IEKAKVAQKK LEAYSQEQVD VLVKALGKVV YDNAEMFAKE AVEETEMGVY 

        70         80         90        100        110        120 
EDKVAKCHLK SGAIWNHIKD KKTVGIIKEE PERALVYVAK PKGVVAATTP ITNPVVTPMC 

       130        140        150        160        170        180 
NAMAAIKGRN TIIVAPHPKA KKVSAHTVEL MNAELKKLGA PENIIQIVEA PSREAAKELM 

       190        200        210        220        230        240 
ESADVVIATG GAGRVKAAYS SGRPAYGVGP GNSQVIVDKG YDYNKAAQDI ITGRKYDNGI 

       250        260        270        280        290        300 
ICSSEQSVIA PAEDYDKVIA AFVENGAFYV EDEETVEKFR STLFKDGKIN SKIIGKSVQI 

       310        320        330        340        350        360 
IADLAGVKVP EGTKVIVLKG KGAGEKDVLC KEKMCPVLVA LKYDTFEEAV EIAMANYMYE 

       370        380        390        400        410        420 
GAGHTAGIHS DNDENIRYAG TVLPISRLVV NQPATTAGGS FNNGFNPTTT LGCGSWGRNS 

       430        440        450 
ISENLTYEHL INVSRIGYFN KEAKVPSYEE IWG

P38947 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools