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UniProtKB/Swiss-Prot entry P38681


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NIR_NEUCR
Primary accession number P38681
Secondary accession number Q7RVB5
Integrated into Swiss-Prot on February 1, 1995
Sequence was last modified on December 4, 2007 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 69)
Name and origin of the protein
Protein name Nitrite reductase [NAD(P)H]
Synonym EC 1.7.1.4
Gene name
Name: nit-6
ORFNames: NCU04720
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
PubMed=8096840 [NCBI, ExPASy, EBI, Israel, Japan]
Exley G.E., Colandene J.D., Garrett R.H.;
"Molecular cloning, characterization, and nucleotide sequence of nit-6, the structural gene for nitrite reductase in Neurospora crassa.";
J. Bacteriol. 175:2379-2392(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L07391; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AABX02000016; EAA31119.2; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A49848; A49848.
3D structure databases
ModBase P38681.
Enzyme and pathway databases
BioCyc MetaCyc:MON-12533; -.
Family and domain databases
InterPro IPR007419; BFD_Fer2_bd.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR006066; Nir_Si_BS.
IPR006067; Nir_Sir_4Fe4S.
IPR005117; NiRdtase/SiRdtase_haem-b_fer.
IPR012744; Nitri_red_NirB.
IPR012748; Nitri_red_NirD.
IPR001327; Pyr_OxRdtase_NAD_bd.
IPR000103; Pyridine_nuc-diS_OxRdtase_2.
IPR005806; Rieske_reg.
Graphical view of domain structure.
Pfam PF04324; Fer2_BFD; 1.
PF01077; NIR_SIR; 1.
PF03460; NIR_SIR_ferr; 1.
PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF00355; Rieske; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00469; PNDRDTASEII.
PR00397; SIROHAEM.
TIGRFAMs TIGR02378; nirD_assim_sml; 1.
TIGR02374; nitri_red_nirB; 1.
PROSITE PS00365; NIR_SIR; 1.
PS51296; RIESKE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P38681.
Genome annotation databases
NMPDR fig|5141.1.peg.2010; -.
Other
ProtoNet P38681.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
2Fe-2S; 4Fe-4S; Complete proteome; FAD; Flavoprotein; Heme; Iron; Iron-sulfur; Metal-binding; NADP; Nitrate assimilation; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1176  1176     Nitrite reductase [NAD(P)H]. PRO_0000199960
DOMAIN   942   1094  153     Rieske; atypical. 
NP_BIND   26     60  35     FAD (Potential). 
NP_BIND   183    215  33     NAD or NADP (Potential). 
COMPBIAS   998   1054  57     Pro/Ser-rich. 
METAL   717    717        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   723    723        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   757    757        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   761    761        Iron (siroheme axial ligand) (By similarity). 
METAL   761    761        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   981    981        Iron-sulfur (2Fe-2S) (By similarity). 
METAL   983    983        Iron-sulfur (2Fe-2S); via pros nitrogen (By similarity). 
METAL   1058   1058        Iron-sulfur (2Fe-2S) (By similarity). 
METAL   1061   1061        Iron-sulfur (2Fe-2S); via pros nitrogen (By similarity). 
CONFLICT   357    357        T -> S (in Ref. 1; L07391). 
Sequence information
Length: 1176 AA [This is the length of the unprocessed precursor] Molecular weight: 127382 Da [This is the MW of the unprocessed precursor] CRC64: 00CAA27C94D6A564 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MANTSLDMAS STSPSPSPES TTTPRKRIVV VGLGMVGIAF IEKLIKLDTQ RQYEIVVIGE 

        70         80         90        100        110        120 
EPHVAYNRVG LTSFFSHREV EQLYLNPLEW YKQHLQTSSL THHLSTAALS LSPATKSLTI 

       130        140        150        160        170        180 
SPPPSTPSLT TLPYDHLILA TGSSALLPTS TPGHDASGVF VYRNIADLQS LITWSSDTQI 

       190        200        210        220        230        240 
KGSTGVVVGG GLLGLEAAKA LMDLQVFGRV VVIERNGWVL SRQVDGEAGA LVLEGVRGLG 

       250        260        270        280        290        300 
VEVLTRKRVK EVECDESKDE GEKEKKRVKG IRFEDGEYLA CSTICFAIGI KARDELAREA 

       310        320        330        340        350        360 
GITCAERGGG GIVVDDSLQT SAPDVYAIGE CASWKGQTFG LIGPGVEMAD VLAFNFTQAH 

       370        380        390        400        410        420 
LHTPRVFKRP DLSTKLKLLG VEVASFGDFF ADRDGPKELP PKLRRELKKS GGKAEVKALT 

       430        440        450        460        470        480 
YKDPFLSVYK KYIFTSDGKY LLGGMMIGDT TDYVRLVPLV KTHKELDVPP SQLILGAKKS 

       490        500        510        520        530        540 
GDDNGDDDLP DDTQICSCHN VTKADLVAPL KSGECTSLGD LKSCTKAGTG CGGCMPLVTS 

       550        560        570        580        590        600 
IFNRTMASLG TEVKNNLCPH FPEYSRADLY NIISVKRLRT LPDVMREAGA DADSLGCEAC 

       610        620        630        640        650        660 
KPAIASIFAS LWNDHVMSPA HHGLQDTNDR FMGNIQRNGT FSVVPRVAAG EITPEKLIVI 

       670        680        690        700        710        720 
GEVAKEYNLY TKITGGQRID MFGAKKQDLL KIWKKLVDAG MESGHAYAKS LRTVKSCVGT 

       730        740        750        760        770        780 
TWCRYGVGDS VGMAVRLEER YKGLRGPHKI KGGVSGCTRE CAEAGNKDFG LIATEKGFNI 

       790        800        810        820        830        840 
LICGNGGTTP KHSVLLAKDV PPTNVIPIID RFLMFYIRTA DKLQRTARWL EALPGGIDYL 

       850        860        870        880        890        900 
KEVILEDRLG ICASLEAQMQ ELVDSYFDEW AEALNNPAMQ ERFKQFANTD EGQPPMEVEI 

       910        920        930        940        950        960 
DRGQERPVMW PREDEGGSAK ADFKGLRDKW SSTTWQPVLE ASYFQGADDL PNGISASIKR 

       970        980        990       1000       1010       1020 
GDTQLAVWRI KGKYYASQQM CPHKRTFALS DGFVGTDPSP SSCSSSALPP SPPSTPPRSS 

      1030       1040       1050       1060       1070       1080 
SPVTSPPQSP TSSATPATTA SSSCTTNPSG PASPWISCPF HKRNFSLTSG SCKNDNELSI 

      1090       1100       1110       1120       1130       1140 
ATFDVEERDD GMVYIKLPPV DELDRELGTK KWMVKKGEAG EGQLRELDEL NKSKGVEGKK 

      1150       1160       1170 
GRRGRKPGAS EAGKEVGKKL VEAVGGGGCG GPGLEW 

P38681 in FASTA format

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