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UniProtKB/Swiss-Prot entry P38670


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ERG24_NEUCR
Primary accession number P38670
Secondary accession number Q7RV50
Integrated into Swiss-Prot on February 1, 1995
Sequence was last modified on February 1, 1995 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 65)
Name and origin of the protein
Protein name Delta(14)-sterol reductase
Synonyms EC 1.3.1.70
C-14 sterol reductase
Sterol C14-reductase
Gene name
Name: erg-3
Synonyms: erg3
ORFNames: B2G14.010, NCU08762
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
Papavinasasundaram K.G., Kasbekar D.P.;
"The Neurospora crassa erg3 gene encodes a protein with sequence homology to both yeast sterol C-14 reductase and chicken lamin B receptor.";
J. Genet. 73:33-41(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1093/nar/gkg293; PubMed=12655011 [NCBI, ExPASy, EBI, Israel, Japan]
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence.";
Nucleic Acids Res. 31:1944-1954(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X77955; CAA54919.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX284753; CAD70446.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000017; EAA26875.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S44170; S44170.
RefSeq XP_956111.1; -.
3D structure databases
ModBase P38670.
Enzyme and pathway databases
BioCyc NCRA-XX3-01:NCRA-XX3-01-003621-MON; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0050613; Molecular function: delta14-sterol reductase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0016126; Biological process: sterol biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001171; ERG4_ERG24.
Graphical view of domain structure.
Pfam PF01222; ERG4_ERG24; 1.
Pfam graphical view of domain structure.
PROSITE PS01017; STEROL_REDUCT_1; 1.
PS01018; STEROL_REDUCT_2; 1.
Genome annotation databases
GeneID 3872249; -.
KEGG ncr:NCU08762; -.
NMPDR fig|5141.1.peg.8812; -.
Other
ProtoNet P38670.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Lipid synthesis; Membrane; NADP; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   490  490     Delta(14)-sterol reductase. PRO_0000207497
TRANSMEM   23    43  21     Potential. 
TRANSMEM   80   100  21     Potential. 
TRANSMEM   136   156  21     Potential. 
TRANSMEM   160   180  21     Potential. 
TRANSMEM   230   250  21     Potential. 
TRANSMEM   255   275  21     Potential. 
TRANSMEM   324   344  21     Potential. 
TRANSMEM   436   456  21     Potential. 
Sequence information
Length: 490 AA [This is the length of the unprocessed precursor] Molecular weight: 54722 Da [This is the MW of the unprocessed precursor] CRC64: 9CF3104EF3014085 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAGKQNQAAP KKAVAPRQQH YEFGGPIGAF GITFGLPILV HVFNLFCNDI SGCPAPSLLH 

        70         80         90        100        110        120 
PKSLDLAQLK REIGWPDNGV FGLFSWSATL WTLGYYALSL VQYRFLPGHH VEGTELSTGG 

       130        140        150        160        170        180 
RLKYKLNAFN SAMCTLAILA AGTIAQGAEF PVWTFISDNF AQIISANILF AFALAIFVYV 

       190        200        210        220        230        240 
RSFDVKPGNK DMRQLAAGGV TGSLIYDFYI GRELNPRITL PLIGQVDIKE FMEMRPGLLG 

       250        260        270        280        290        300 
WIILNCAFIA KQYRLYGYVT DSILFITAIQ AFYVFDGIYM EPAVLTTMDI TTDGFGFMLS 

       310        320        330        340        350        360 
FGDVVWVPFM YSTQTRYLSV HPQQLGAFGL IAVGAVLAAG YSIFRLSNSQ KNNFRTNPED 

       370        380        390        400        410        420 
PSVKHLTYLQ TKTGSRLITS GWWGIARHIN YLGDWLQSWP YSLPTGIAGY QILSAGSNAP 

       430        440        450        460        470        480 
GAITMLDGRE VVQGEARGWG IVFTYFYILY FAILLIHRDL RDDEKCSKKY GDDWEKYKKL 

       490 
VKWRIVPGIY 

P38670 in FASTA format

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