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UniProtKB/Swiss-Prot entry P37201

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NCPR_CANTR
Primary accession number P37201
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1994
Sequence was last modified on October 1, 1994 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name NADPH--cytochrome P450 reductase
Synonyms CPR
P450R
EC 1.6.2.4
Gene name
Name: NCP1
Synonyms: CPR
From
Candida tropicalis (Yeast) [TaxID: 5482] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2118906 [NCBI, ExPASy, EBI, Israel, Japan]
Sutter T.R., Sanglard D., Loper J.C.;
"Isolation and characterization of the alkane-inducible NADPH-cytochrome P-450 oxidoreductase gene from Candida tropicalis. Identification of invariant residues within similar amino acid sequences of divergent flavoproteins.";
J. Biol. Chem. 265:16428-16436(1990).
[2]
 ERRATUM.
Sutter T.R., Sanglard D., Loper J.C.;
J. Biol. Chem. 265:22056-22056(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M35199; AAA34333.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A37890; A37890.
3D structure databases
HSSP P16435; 1B1C. [HSSP ENTRY / PDB]
ModBase P37201.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0003958; Molecular function: NADPH-hemoprotein reductase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR003097; FAD-binding_1.
IPR001094; Flavdoxin_like.
IPR008254; Flavodoxin/NO_synth.
IPR001709; FPN_cyt_redctse.
IPR015702; NADPH_Cyt_Red.
IPR001433; OxRdtase_FAD/NAD_bd.
Graphical view of domain structure.
PANTHER PTHR19384:SF17; NADPH_Cyt_Red; 1.
Pfam PF00667; FAD_binding_1; 1.
PF00258; Flavodoxin_1; 1.
PF00175; NAD_binding_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00369; FLAVODOXIN.
PR00371; FPNCR.
PROSITE PS51384; FAD_FR; 1.
PS50902; FLAVODOXIN_LIKE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P37201.
Other
ProtoNet P37201.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; FAD; Flavoprotein; FMN; Membrane; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   680  680     NADPH--cytochrome P450 reductase. PRO_0000167606
TRANSMEM   8    24  17     Potential. 
DOMAIN   60   204  145     Flavodoxin-like. 
DOMAIN   264   509  246     FAD-binding FR-type. 
NP_BIND   149   180  32     FMN (By similarity). 
NP_BIND   304   315  12     FAD (By similarity). 
NP_BIND   435   446  12     FAD (By similarity). 
NP_BIND   532   550  19     NADP (By similarity). 
NP_BIND   628   644  17     NADP (By similarity). 
Sequence information
Length: 680 AA [This is the length of the unprocessed precursor] Molecular weight: 76689 Da [This is the MW of the unprocessed precursor] CRC64: AB31ABFF8ADA41DA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MALDKLDLYV IITLVVAIAA YFAKNQFLDQ QQDTGFLNTD SGDGNSRDIL QALKKNNKNT 

        70         80         90        100        110        120 
LLLFGSQTGT AEDYANKLSR ELHSRFGLKT MVADFADYDF ENFGDITEDI LVFFIVATYG 

       130        140        150        160        170        180 
EGEPTDNADE FHTWLTEEAD TLSTLKYTVF GLGNSTYEFF NAIGRKFDRL LGEKGGDRFA 

       190        200        210        220        230        240 
EYGEGDDGTG TLDEDFLAWK DNVFDSLKND LNFEEKELKY EPNVKLTERD DLSGNDPDVS 

       250        260        270        280        290        300 
LGEPNVKYIK SEGVDLTKGP FDHTHPFLAR IVKTKELFTS EDRHCVHVEF DISESNLKYT 

       310        320        330        340        350        360 
TGDHLAIWPS NSDENIKQFA KCFGLEDKLD TVIELKALDS TYSIPFPNPI TYGAVIRHHL 

       370        380        390        400        410        420 
EISGPVSRQF FLSIAGFAPD EETKKSFTRI GGDKQEFASK VTRRKFNIAD ALLFASNNRP 

       430        440        450        460        470        480 
WSDVPFEFLI ENVQHLTPRY YSISSSSLSE KQTINVTAVV EAEEEADGRP VTGVVTNLLK 

       490        500        510        520        530        540 
NIEIEQNKTG ETPMVHYDLN GPRGKFSKFR LPVHVRRSNF KLPKNSTTPV ILIGPGTGVA 

       550        560        570        580        590        600 
PLRGFVRERV QQVKNGVNVG KTVLFYGCRN SEQDFLYKQE WSEYASVLGE NFEMFNAFSR 

       610        620        630        640        650        660 
QDPTKKVYVQ DKILENSALV DELLSSGAII YVCGDASRMA RDVQAAIAKI VAKSRDIHED 

       670        680 
KAAELVKSWK VQNRYQEDVW
P37201 in FASTA format

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